Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation

In conclusion, a novel approach has been developed to dynamically model SCRE at the tissue scale, which facilitates novel, detailed multi-scale mechanistic analysis. It was revealed that complex re-entrant excitation patterns and SCRE may be bi-directionally coupled, promoting novel mechanisms of arrhythmia perpetuation.
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research

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Sensors, Vol. 19, Pages 3969: Enabling Heart Self-Monitoring for All and for AAL—Portable Device within a Complete Telemedicine System Sensors doi: 10.3390/s19183969 Authors: Andrés-Lorenzo Bleda Francisco-Manuel Melgarejo-Meseguer Francisco-Javier Gimeno-Blanes Arcadi García-Alberola José Luis Rojo-Álvarez Javier Corral Ricardo Ruiz Rafael Maestre-Ferriz During the last decades there has been a rapidly growing elderly population and the number of patients with chronic heart-related diseases has exploded. Many of them (such as those with congestive heart failure or so...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
ConclusionThe overall estimated incidence of AF and recurrent AF during pregnancy is as high as 2.2% and 39.2%, respectively. AF during pregnancy may result in poor maternal and fetal outcomes.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
CONCLUSION: The overall estimated incidence of AF and recurrent AF during pregnancy is as high as 2.2% and 39.2%, respectively. AF during pregnancy may result in poor maternal and fetal outcomes. PMID: 31521944 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - Category: Biomedical Science Authors: Tags: Adv Med Sci Source Type: research
Publication date: Available online 9 September 2019Source: Indian Heart JournalAuthor(s): Rajkumar Doshi, Mohamed Taha, Mihir Dave, Rupak Desai, Nageshwara GullapalliAbstractBackgroundThe aim of this study is to analyze sex-specific readmission rates, etiology, and predictors of readmission after transcatheter aortic valve replacement (TAVR). Readmissions post-TAVR is common, contributing to increased healthcare utilization and costs. Many factors have been discovered as predictors of readmission, however, sex-specific disparities in readmission ratesis limited.MethodsBetween January 2012 and September 2015, adult patients...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
DiscussionRemote monitoring may improve clinical outcome if it uncovers conditions with low symptom burden which cause or indicate an increased risk. A simple and easily implementable response to the information is important. Cardiac arrhythmias frequently start as asymptomatic, shorter lasting, and nightly events. The BIO-GUARD-MI trial represents the first attempt to simplify the response to the rather complex nature of heart arrhythmias.Trial registrationClinical Trials,NCT02341534. Registered on 19 January 2015.
Source: Trials - Category: Research Source Type: clinical trials
In conclusion, the effects of AADs are highly complex and strongly dependent on the experimental or clinical conditions. MANTA is a powerful and freely available tool reproducing a wide range of AAD characteristics that enables analyses of the underlying ionic mechanisms. Use of MANTA is expected to improve our understanding of AAD effects on cellular electrophysiology under a wide range of conditions, which may provide clinically-relevant information on the safety and efficacy of AAD treatment.Graphical abstract
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conclusion Second-generation CB-A of atrial fibrillation seems feasible and safe in patients with heart failure with reduced ejection fraction and heart failure with mid-range ejection fraction, in terms of complications rate and number of applications per vein. All pulmonary veins could be isolated with the 28-mm cryoballoon advance only.
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Arrhythmias Source Type: research
Authors: Kim DY, Kim SH, Ryu KH Abstract Recent studies on radiofrequency catheter ablation (RFCA) in atrial fibrillation show its effectiveness in heart failure (HF) patients; hence, tachycardia-induced cardiomyopathy (T-CMP) is gaining attention. Tachycardia-mediated cardiomyopathy is a reversible left ventricular (LV) dysfunction, which can be induced by any tachyarrhythmia. Early recognition of T-CMP with appropriate treatment of the arrhythmia culprit will lead to the recovery of LV function. Patients with tachycardia and LV dysfunction should be suspected of having T-CMP, with or without established etiology ...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Hypertension is the most common cardiovascular risk factor and underlies heart failure, coronary artery disease, stroke, and chronic kidney disease. Hypertensive heart disease can manifest as cardiac arrhythmias. Supraventricular and ventricular arrhythmias may occur in the hypertensive patients. Atrial fibrillation and hypertension contribute to an increased risk of stroke. Some antihypertensive drugs predispose to electrolyte abnormalities, which may result in atrial and ventricular arrhythmias. A multipronged strategy involving appropriate screening, aggressive lifestyle modifications, and optimal pharmacotherapy can re...
Source: Heart Failure Clinics - Category: Cardiology Authors: Source Type: research
ConclusionsNMES is feasible in patients with AHF from immediately after admission.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
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