Degradation of extracellular matrices propagates calcification during development and healing in bones and teeth

ConclusionThe ECM proteins may inhibit mineral deposition and calcification, similar to the role of amelogenin during enamel development. The candidates for the amelogenin equivalents in bone and dentin have not been identified. Further studies are required to elucidate the regulatory mechanisms of bone and dentin calcification in light of specific ECM proteins that prevent calcification and enzymes that degrade these ECM proteins.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research