Regulation of osteoclast function via Rho-Pkn3-c-Src pathways

ConclusionWnt5a-Ror2 signaling promotes the bone-resorbing activity of osteoclasts by activating the Daam2-Rho-Pkn3-c-Src pathways. Pkn3 inhibitors, therefore, have potential as therapeutic agents for osteoporosis and bone destruction in inflammatory diseases.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research