A vicious cycle of {beta} amyloid-dependent neuronal hyperactivation

β-amyloid (Aβ)–dependent neuronal hyperactivity is believed to contribute to the circuit dysfunction that characterizes the early stages of Alzheimer’s disease (AD). Although experimental evidence in support of this hypothesis continues to accrue, the underlying pathological mechanisms are not well understood. In this experiment, we used mouse models of Aβ-amyloidosis to show that hyperactivation is initiated by the suppression of glutamate reuptake. Hyperactivity occurred in neurons with preexisting baseline activity, whereas inactive neurons were generally resistant to Aβ-mediated hyperactivation. Aβ-containing AD brain extracts and purified Aβ dimers were able to sustain this vicious cycle. Our findings suggest a cellular mechanism of Aβ-dependent neuronal dysfunction that can be active before plaque formation.
Source: ScienceNOW - Category: Science Authors: Tags: Medicine, Diseases, Neuroscience r-articles Source Type: news

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CONCLUSIONS: Our study results corroborate earlier findings that the CSF tool is of added value to the diagnostic workup in daily clinical practice outside tertiary referral centers. CSF levels can best be used in patients under 66 years of age. Given the limited use of this tool in settings outside research facilities, we recommend that the usefulness of CSF biomarkers is studied in a multicenter study. When in the future CSF levels can be reliably measured in plasma, this may become even more relevant. PMID: 32224618 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Publication date: Available online 2 April 2020Source: Social Science &MedicineAuthor(s): Sae Hwang Han, J. Scott Roberts, Jan E. Mutchler, Jeffrey A. Burr
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Authors: Khosravi S, Harner ME Abstract Mitochondria perform a plethora of functions in various cells of different tissues. Their architecture differs remarkably, for instance in neurons versus steroidogenic cells. Furthermore, aberrant mitochondrial architecture results in mitochondrial dysfunction. This indicates strongly that mitochondrial architecture and function are intimately linked. Therefore, a deep knowledge about the determinants of mitochondrial architecture and their function on a molecular level is of utmost importance. In the past decades, various proteins and protein complexes essential for formatio...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
In conclusion, intravenous neuronal mitochondria-targeted dual-modified novel biomimetic nanosystems are a promising therapeutic candidate for ROS-induced mitochondrial dysfunction in AD. PMID: 32228100 [PubMed - in process]
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
No abstract available
Source: Neurology Today - Category: Neurology Tags: In the Pipeline Source Type: research
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Source: Journal of American College Health - Category: Universities & Medical Training Authors: Source Type: research
In conclusion, the different severities of glaucoma do not alter the incidence of subsequent dementia.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
WEDNESDAY, April 1, 2020 -- A new study dispels a common belief about how stimulants such as Ritalin and Adderall work in the brain. The drugs are usually prescribed to people with attention deficit hyperactivity disorder (ADHD), but are sometimes...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC09758A, Feature ArticleMadhuparna Roy, Ishita Pal, Arnab K Nath, Somdatta Ghosh Dey The amyloid cascade theory attributes the neurodegeneration observed in Alzheimer ’s disease (AD) to the deposition of amyloid β (Aβ) peptide into plaques and fibrils in the AD brain. The metal... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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