Assessment of significant procedures in multigene molecular detection for breast cancer in clinical laboratories: from variant detection to targeted therapy.

CONCLUSION: The variant detection capability was satisfactory, but the ability to provide accuracy and comprehensive targeted drug information should be urgently improved. Our study summarized a completed NGS-based multigene molecular detection pipeline, aiming to better inform precision treatment for breast cancer patients. PMID: 31388961 [PubMed - as supplied by publisher]
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research

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Publication date: Available online 20 September 2019Source: Biocybernetics and Biomedical EngineeringAuthor(s): Tasleem Kausar, MingJiang Wang, Muhammad Idrees, Yun LuAbstractAmong the predominant cancers, breast cancer is one of the main causes of cancer deaths impacting women worldwide. However, breast cancer classification is challenging due to numerous morphological and textural variations that appeared in intra-class images. Also, the direct processing of high resolution histological images is uneconomical in terms of GPU memory. In the present study, we have proposed a new approach for breast histopathological image ...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Publication date: Available online 20 September 2019Source: International Journal of Surgery Case ReportsAuthor(s): Shin Takayama, Kaishi Satomi, Masayuki Yoshida, Chikashi Watase, Takeshi Murata, Sho Shiino, Kenjiro Jimbo, Akihiko SutoABSTRACTINTRODUCTIONSpontaneous regression of a malignant tumor is defined as “the partial or complete disappearance of a malignant tumor in the absence of any treatment.” Herein, we report a case of occult breast cancer with axillary lymph node metastasis that showed spontaneous tumor regression based on the histopathological findings.PRESENTATION OF THE CASEA 67-year-old woman ...
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Authors: Kikuchi K, Miki A, Satoh H, Iba N, Sato-Sakuma R, Beppu H, Sawada Y Abstract Patient narratives of adverse drug events (ADEs) often differ from the symptoms listed on the package inserts of pharmaceutical products using common ADE terminology and could be a source of great comfort to patients with the same disease. To explore this idea, we analyzed written narratives obtained from 48 patients with breast cancer using the NPO Corporation Database of Individual Patients' Experiences, Japan (DIPEx-Japan). Our analysis aimed to determine the utility of an "Adverse Drug Event Database" for use in clin...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
Abstract: Everolimus is a mammalian target of rapamycin (m-TOR) inhibitor that has been approved for the treatment of hormone receptor-positive advanced breast cancer, metastatic renal cancer, and neuroendocrine tumors. Although therapeutic drug monitoring (TDM) of everolimus is well established in the transplantation field, it is not currently performed in oncology. The last consensus conference about the TDM of everolimus states that for the use of everolimus in oncology, “further studies are required to determine the clinical utility of TDM for everolimus in oncology settings.” In this review, the authors ...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Conclusions: The abnormal location of FLT3 caused by different glycosylation status leads to the distinguishing signaling pathways. Targeting on FLT3 glycosylation may provide a new perspective for therapeutic strategies. Abbreviations: ABCG2: ATP-binding cassette transporter breast cancer resistance protein; ATF: activating transcription factor; AML: acute myeloid leukemia; CHOP: CCAAT-enhancer-binding protein homologous protein; 2-DG: 2-deoxy-D-glucose; EFS: event free survival; EPO: erythropoietin; EPOR: erythropoietin receptor; ERS: endoplasmic reticulum stress; FLT3: FMS-like tyrosine kinase 3; GPI: glycosylphosphatid...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
We describe the case of a 52-year-old female outpatient who developed OIC while receiving oxycodone for pain due to cancer with multiple bone metastases. Although she did not have brain metastasis, opioid withdrawal syndrome (OWS) developed after taking naldemedine orally. Her Clinical Opiate-Withdrawal Score (COWS) was 19 (moderate symptoms). However, she recovered from OWS on intravenous fentanyl and a continuous infusion of oxycodone. She did not develop OWS thereafter and was discharged two days after recovery. PMID: 31534081 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Contributors : Na Hao ; Rong Xiang ; Yunping LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of MDA-MB-231 breast tumor cell from knocking-down phosphodiesterase 3A (PDE3A), a cyclic nucleotide phosphodiesterase. Results provide insight into the role of PDE3A in breast tumor progression and metastasis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Every IVF cycle involves an element of uncertainty in the sense that the outcome cannot be predicted and you can never be sure whether you'll get pregnant in your first cycle or whether you will get pregnant in your fourth. And which is why patients aren't sure whether they should give up or maybe change the doctor or consider third party reproduction.Yes, it's true that every cycle entails a risk, but you need to remember that this risk is predominantly financial and emotional. As far as medical risks go, if you're doing IVF in a good clinic, you don't need to worry about the impact either on your own body or on that of t...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Publication date: Available online 19 September 2019Source: Nitric OxideAuthor(s): Marianela Sciacca, Denise Belgorosky, Macarena Zambrano, José Ignacio Gomez Escalante, Fernanda Roca, Yanina V. Langle, Eduardo O. Sandes, Catalina Lodillinsky, Ana María EijánAbstractNitric Oxide (NO) is involved in many physiological and pathological processes. It is generated by a family of NO synthases (NOS), being the inducible isoform, iNOS, responsible for higher amounts of NO. Here, we report that pharmacological inhibition of NO production by l-NAME reduces both viability and MAPK activated signalling pathways i...
Source: Nitric Oxide - Category: Chemistry Source Type: research
Authors: Niu J, Ma J, Guan X, Zhao X, Li P, Zhang M Abstract BACKGROUND The aim of this study was to assess the correlation between Doppler ultrasound blood flow parameters and angiogenesis and proliferation activity in breast cancer. MATERIAL AND METHODS We enrolled breast cancer patients (n=55) and benign tumor patients (n=40) from Tengzhou Central People's Hospital from Mar 2014 to Dec 2016. Doppler ultrasound examination was conducted to determine blood flow parameters, and immunohistochemistry (IHC) experiments were performed to determine the protein expression of angiogenesis genes, cell proliferation genes, ...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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