Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms

In this study we addressed this issue, testing the hypothesis that limbic changes in tinnitus relate to both disease-related distress as well as co-morbid psychopathology. We obtained high-resolution structural magnetic resonance imaging (MRI) scans from a total of 125 subjects: 59 patients with bilateral chronic tinnitus (29 with a co-morbid psychiatric condition, 30 without), 40 healthy controls and 26 psychiatric controls with depression/anxiety disorders (without tinnitus). Voxel-based morphometry with the CAT12 software package was used to analyse data. First, we analysed data based on a 2 × 2 factorial design (tinnitus; psychiatric co-morbidity), showing trend-level effects for tinnitus in ROI analyses of the anterior cingulate cortex and superior/transverse temporal gyri, and for voxel-based analysis in the left parahippocampal cortex. Multiple regression analyses showed that the parahippocampal finding was mostly predicted by tinnitus rather than (dimensional) psychopathology ratings. Comparing only low-distress tinnitus patients (independent of co-morbid conditions) with healthy controls also showed reduced left parahippocampal grey matter. Our findings demonstrate that depression and anxiety (not only subjective distress) are major modulators of brain structural effects in tinnitus, calling for a stronger consideration of psychopathology in future neurobiological and clinical studies of tinnitus.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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CONCLUSIONS: Our findings contribute to the growing understanding of the power of social connectedness as building shared social identity when living with tinnitus. Statement of contribution What is already known on this subject? Tinnitus is a prevalent condition with approximately 10-15% of the population experiencing a spontaneous sound without obvious source. Tinnitus is an invisible health and chronic condition. People with tinnitus experience high levels of distress, anxiety, and depression. Group support is beneficial to people with many health problems. What does this study add? This study describes the mechanisms b...
Source: British Journal of Health Psychology - Category: Psychiatry & Psychology Authors: Tags: Br J Health Psychol Source Type: research
Conclusions Results from this study suggest support for the predominant clinical view that patients with tinnitus and hyperacusis have higher levels of anxiety and depression than the general population. The extent of the suffering described and patterns of coping strategies suggest clinical practice patterns and the need for research in implementing improved practice plans. PMID: 31430190 [PubMed - as supplied by publisher]
Source: American Journal of Audiology - Category: Audiology Authors: Tags: Am J Audiol Source Type: research
Conclusions Clinicians who offer tinnitus and hyperacusis rehabilitation should screen for suicidal and self-harm ideations among patients, especially for those with symptoms of depression and a childhood history of parental mental illness. Patients with suicidal and self-harm ideations should be referred to mental health services for further diagnosis and treatment. PMID: 31184510 [PubMed - as supplied by publisher]
Source: American Journal of Audiology - Category: Audiology Authors: Tags: Am J Audiol Source Type: research
Severe tinnitus has been shown to be strongly associated with depression and anxiety, and the only established approach to treat tinnitus is cognitive behavioral therapy. Our research group recently reported that the tinnitus-associated mental health bu...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
This study used responses to a questionnaire from about 72,000 adults in Sweden to examine whether an association with increased risk of suicide attempts might be different between men and women.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 28 April 2019Source: Neuroscience LettersAuthor(s): Yaping XuAbstractThe study investigated the alteration of brain functional connectivity (FC) patterns and analyzed the relationship between FC and psychological statue in pulsatile tinnitus (PT) patients by resting-state functional magnetic resonance imaging. The eligible PT patients (29) and healthy subjects (29) were enrolled. Brain activity, FC and clinical characteristics, including tinnitus handicap inventory, duration, sleep quality, anxiety, and depression were evaluated. A significantly increased brain activity in the left cerebe...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Conclusions Overall, the results of this study indicate that the K-TPFQ is reliable and valid. Therefore, the current translated version of the K-TPFQ is applicable to subjects with Korean as their 1st language and proves to be a useful tinnitus questionnaire. PMID: 31021659 [PubMed - as supplied by publisher]
Source: American Journal of Audiology - Category: Audiology Authors: Tags: Am J Audiol Source Type: research
Conclusions: To our knowledge, this is the first study to investigate VS-related tinnitus with respect to both patients' hearing status and psychological condition. Our results suggest that tinnitus distress strongly affects VS patients' QoL and that its characteristics are similar to primary tinnitus. An intervention for VS-related tinnitus, therefore, should assess to what extent tinnitus bothers patients, and it should reduce any unpleasant emotions that may exacerbate symptoms. This approach should improve their QoL. Introduction Vestibular schwannoma (VS)—or acoustic neuroma—is a be...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion Findings suggest that Veterans who are diagnosed with tinnitus have more health care utilization and are more frequently diagnosed with mental health disorders than Veterans who are not diagnosed with tinnitus. This suggests a need for coordinated tinnitus and mental health care services for Veterans in the VA system of care. PMID: 31022360 [PubMed - in process]
Source: American Journal of Audiology - Category: Audiology Authors: Tags: Am J Audiol Source Type: research
Publication date: Available online 1 April 2019Source: NeuroscienceAuthor(s): Tengfei Qu, Yue Qi, Shukui Yu, Zhengde Du, Wei Wei, Aoling Cai, Jie Wang, Binbin Nie, Ke Liu, Shusheng GongAbstractTinnitus is thought to be triggered by aberrant neural activity in the central auditory pathway and is often accompanied by comorbidities of emotional distress and anxiety, which imply maladaptive functional connectivity to limbic structures, such as the amygdala and hippocampus. Tinnitus patients with normal audiograms can also have accompanying anxiety and depression, clinically. To test the role of functional connectivity between ...
Source: Neuroscience - Category: Neuroscience Source Type: research
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