Asthma from immune pathogenesis to precision medicine.

Asthma from immune pathogenesis to precision medicine. Semin Immunol. 2019 Aug 03;:101294 Authors: Khalaf K, Paoletti G, Puggioni F, Racca F, De Luca F, Giorgis V, Canonica GW, Heffler E Abstract Asthma is characterized by multiple immunological mechanisms (endotypes) determining variable clinical presentations (phenotypes). The identification of endotypic mechanisms is crucial to better characterize patients and to identify tailored therapeutic approaches with novel biological agents targeting specific immunological pathways. This review focused on summarizing the major immunological mechanisms involved in the pathogenesis of asthma, as well as on discussing the emergence of phenotypic features of the disease. Novel biological agents and other drugs targeting specific endotypes are discussed, as their use represent a precision medicine approach to the disease that is nowadays mandatory particularly for treating more severe patients. PMID: 31387788 [PubMed - as supplied by publisher]
Source: Seminars in Immunology - Category: Allergy & Immunology Authors: Tags: Semin Immunol Source Type: research