Parkinson’s disease: The sign in the skin that could signal the brain condition

PARKINSON ’S disease is a progressive disease of the nervous system marked by certain symptoms. If you notice a change in your skin it could mean you are at risk. Have you noticed this?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Conditions:   Parkinson Disease;   Healthy Volunteer Intervention:   Drug: [18F]NOS Sponsor:   University of Pennsylvania Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Parkinson Disease;   Cognitive Dysfunction;   Biomarkers Intervention:   Diagnostic Test: serum alpha synuclein autoantibodies, motor and non motor scales Sponsor:   Ain Shams University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 19 August 2019Source: NeuroImage: ClinicalAuthor(s): Yashar Zeighami, Seyed-Mohammad Fereshtehnejad, Mahsa Dadar, D. Louis Collins, Ronald B. Postuma, Alain DagherAbstractBackgroundCommonly used neuroimaging biomarkers in Parkinson's disease (PD) are useful for diagnosis but poor at predicting outcomes. We explored whether an atrophy pattern from whole-brain structural MRI, measured in the drug-naïve early stage, could predict PD prognosis.Methods362 de novo PD patients with T1-weighted MRI (n = 222 for the main analysis, 140 for the validation analysis) were recruited from the P...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC04251B, CommunicationAnindita Mahapatra, Sukanya Sarkar, Subhas Chandra Biswas, Krishnananda Chattopadhyay Parkinson ’s disease (PD), closely associated with the misfolding and aggregation of the neuronal protein α-Synuclein (Α-Syn), is a neurodegenerative disorder with no cure till date. Here, we show that the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Condition:   Parkinson Disease Intervention:   Procedure: Response Inhibition and Deep Brain Stimulation in Parkinson's disease Sponsor:   University of Alabama at Birmingham Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 18 August 2019Source: NeuroImage: ClinicalAuthor(s): Eva Matt, Florian Ph.S. Fischmeister, Thomas Foki, Roland BeisteinerAbstractApraxia is a deficit in central motor planning impairing praxis functions such as gesture production or tool use that affects a substantial number of patients with advanced Parkinson's disease. We investigated the functional connectivity of the praxis network in patients in early stages of Parkinson's disease having an increased risk for apraxia and evaluated the influence of dopaminergic therapy on praxis abilities and related networks.13 patients with mild to ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 10 August 2019Source: Life SciencesAuthor(s): Haining Li, Juan Yang, Yanbai Wang, Qiang Liu, Jiang Cheng, Feng WangAbstractAimsThe present study was aimed to investigate the neuroprotective effect of HSP70 against neuroinflammation in a rotenone-induced Parkinson's disease model.Materials and methodsIn the present study, SH-SY5Y cells were treated with HSP70 (5–20 mg/L) for 72 h. Cell viability, reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), levels of oxidative markers, mitochondrial fragmentation, apoptosis, and mRNA and protein expressions of sig...
Source: Life Sciences - Category: Biology Source Type: research
People living with brain and nerve conditions like Parkinson ’s could benefit from quicker diagnosis and better coordinated care as part of a new NHS initiative.
Source: NHS Networks - Category: UK Health Source Type: news
Semin Speech Lang DOI: 10.1055/s-0039-1694997 Background and Purpose The aim of the study was to compare transcription-based speech intelligibility and scaled speech severity for the detection of mild speech impairments, by studying these metrics across talkers with Parkinson's disease (PD), age- and sex-matched older adults, and younger adults. An additional aim was to determine the impact of listener experience on these clinical measures. Methods Fifteen speakers from each experimental group were asked to read aloud 11 randomly generated sentences from the Speech Intelligibility Test at their typical spea...
Source: Seminars in Speech and Language - Category: Speech-Language Pathology Authors: Tags: Review Article Source Type: research
iad Fajloun Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. The venom can be introduced into the human body by manual injection or by direct bee stings. Bee venom contains several active molecules such as peptides and enzymes that have advantageous potential in treating inflammation and central nervous system diseases, such as Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. Moreover, bee venom has shown promising benefits against different types of cancer as well as ant...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
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