The Role of Metabolic Syndrome in Endometrial Cancer: A Review

Endometrial cancer is one of the most common cancers of the female reproductive system. Although surgery, radiotherapy, chemotherapy and hormone therapy can significantly improve the survival of patients, the treatment of patients with very early lesions and a strong desire to retain reproductive function or late recurrence is still in the early stages. Metabolic syndrome (MS) is a clustering of at least three of the five following medical conditions: central obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Obesity, diabetes and hypertension often coexist in patients with endometrial cancer, which increases the risk of endometrial cancer, also known as the "triple syndrome of endometrial cancer". In recent years, epidemiological and clinical studies have found that MS associated with metabolic diseases is closely related to the incidence of endometrial cancer. However, the key molecular mechanisms underlying the induction of endometrial cancer by MS have not been elucidated to date. Characterizing the tumor metabolism microenvironment will be advantageous for achieving a comprehensive view of the molecular mechanism of metabolic syndrome associated with endometrial cancer and for providing a new target for the treatment of endometrial cancer. This review focuses on recent advances in determining the role of metabolic syndrome-related factors and mechanisms in the pat...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Roche today announced that results from a number of studies across its comprehensive oncology portfolio, covering a broad range of cancers including bladder, lung and breast will be presented at the European Society for Medical Oncology (ESMO) 2019 Congress, taking place from 27 September - 1 October in Barcelona, Spain.
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Conclusion: The obesity-related SNP rs545854 was correlated with the serum uric acid level and risk of hyperuricemia in a male Chinese population. Therefore, men carrying this SNP could benefit from limiting their meat consumption to prevent hyperuricemia. These findings suggest an underlying genetic link between obesity and hyperuricemia worthy of further exploration. Introduction Serum uric acid (SUA) is a final product of the metabolic breakdown of purine oxidation (1). Since humans lack the gene for uricase that converts uric acid into a soluble form, the human uric acid level tends to be higher than that of othe...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Kaya S, Kaya B, Keskin HL, Kayhan Tetik B, Yavuz FA Abstract The aim of this study was to assess the relation between benign endometrial pathologies (polyp and/or hyperplasia without atypia) and the metabolic status (insulin resistance and metabolic syndrome) of the patients. A total of 168 cases were enrolled in the study. The patients were classified according to the presence of benign endometrial pathologies and their menopausal status. Then, the subjects were evaluated according to the metabolic syndrome criteria and the presence of an insulin resistance. The insulin resistance levels of the cases were...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
This study has been limited for interpretation due to its small sample size and not being the primary focus of the original study.Coronal view showing bilateral polycystic ovaries.A more recent study compared separately the risk of PCOS and its relations to endometrial, ovarian, and breast cancers, which originally showed on analysis that ovarian cancer was not significant (OR 1.41;95% CI,0.93-2.15 p
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Publication date: Available online 5 April 2017 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Zeinab Faghfoori, Siavash Fazelian, Mahdi Shadnoush, Reza Goodarzi Polycystic ovary syndrome (PCOS) is endocrine disorder in women of reproductive age, which leads to reproductive, hormonal and metabolic abnormalities. Due to the presence of insulin resistance, PCOS increases the risk of chronic diseases like type 2 diabetes, hypertension, lipid disorders, cardiovascular diseases and malignancies such as breast and endometrial cancer. The actual cause of this syndrome is unknown but environm...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: December 2016 Source:European Journal of Obstetrics & Gynecology and Reproductive Biology, Volume 207 Author(s): Vasileios Charalampakis, Abd A. Tahrani, Ahmed Helmy, Janesh K. Gupta, Rishi Singhal One of the most effective methods to tackle obesity and its related comorbidities is bariatric surgery. Polycystic ovary syndrome (PCOS) and endometrial hyperplasia (EH), which are associated with increased risk of endometrial carcinoma, have been identified as potentially new indications for bariatric surgery. PCOS is the most common endocrine disorder in women in the reproductive age and is associated wi...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Patients with endometrial cancer and hyperplasia (EMCA and CAH) is often managed with oophorectomy, with subsequent surgical menopause a major consequence. Estrogen deprivation has a long lasting impact female health, including lipid metabolism. Furthermore, there is a link between increased risk of non-alcoholic fatty liver disease (NAFLD) and advanced age especially after spontaneous menopause. NAFLD is known to be not only a hepatic manifestation of metabolic syndrome related to obesity, diabetes mellitus, hypertension, and hypercholesterolemia but also a possible risk factor for cirrhosis and hepatocellular carcinoma.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Source Type: research
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