Medicare Announces Coverage for CAR T-Cell Therapy Medicare Announces Coverage for CAR T-Cell Therapy

The Centers for Medicare&Medicaid Services has issued a national coverage decision for the costly customized cancer therapy.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

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Biomedical engineers at Duke University have developed a method to address failures in a promising anti-cancer drug, bringing together tools from genome engineering, protein engineering and biomaterials science to improve the efficacy, accuracy and longevity of certain cancer therapies.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
The objectives of this study were to identify the prevalence of severe drug interactions (SDIs) and potentially inappropriate prescriptions (PIPs) in older adults with cancer.MethodsA 12-month prospective observational study of patients ≥65 years admitted to an oncology centre was conducted. SDIs were assessed using Stockley’s interaction checker; PIPs were identified using STOPP/START criteria. Logistic regression was applied to determine the influence of age, gender, co-morbidities and medication number on the likelihood of a n SDI and a PIP.ResultsWe enrolled 186 participants; mean age 72.5 (SD5.7) years, 46.2%...
Source: Age and Ageing - Category: Geriatrics Source Type: research
il Jeoung Epidermal growth factor receptor (EGFR) plays critical roles in cell proliferation, tumorigenesis, and anti-cancer drug resistance. Overexpression and somatic mutations of EGFR result in enhanced cancer cell survival. Therefore, EGFR can be a target for the development of anti-cancer therapy. Patients with cancers, including non-small cell lung cancers (NSCLC), have been shown to response to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) and anti-EGFR antibodies. However, resistance to these anti-EGFR treatments has developed. Autophagy has emerged as a potential mechanism involved in the acquired resistance to ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
AbstractOver the last two decades, a novel subgroup of serine proteases, the cell surface –anchored serine proteases, has emerged as an important component of the human degradome, and several members have garnered significant attention for their roles in cancer progression and metastasis. A large body of literature describes that cell surface–anchored serine proteases are deregulated in cancer and that they contribute to both tumor formation and metastasis through diverse molecular mechanisms. The loss of precise regulation of cell surface–anchored serine protease expression and/or catalytic activity may ...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
In this study, a marked decrease in the incidence of lung cancer (a 67% relative risk reduction) was observed in a high-risk population. Although a number of preclinical studies have demonstrated that canakinumab inhibits interleukin-1β and reduces inflammation, the question remains whether these actions positively affect both cancer incidence and recurrence. This review will summarize the role of inflammation in cancer propagation and development, discuss the biological rationale for targeting interleukin-1β in lung cancer, advocate for further investigation of the anti-inflammatory antibody canakinumab as a new...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Review Article Source Type: research
Publication date: Available online 12 September 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Chun-Nan Kuo, Yu-Ming Liao, Li-Na Kuo, Hui-Ju Tsai, Wei-Chiao Chang, Yun YenCancer is the leading cause of death in Taiwan, and the overall incidence rate has gradually increased. The four most common cancers in Taiwan are colorectal, lung, breast and liver cancers. With the rise in incidence, the clinical use and costs of all anticancer drugs have steadily increased. The costs of novel therapeutics, such as targeted therapies and immunotherapy were accounted almost two-third of all antineoplastic agents in Tai...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Four years ago, Varian’s Applied Research Team, a group separate from its research and development unit, began looking at how to incorporate artificial intelligence into cancer therapy. The team’s hard work has resulted in the development of Ethos, an AI-driven holistic solution designed to increase the efficiency of radiotherapy. MD+DI spoke with Chris Toth, president of Varian Oncology Systems ahead of Ethos’ launch at the American Society for Radiation Oncology [ASTRO] annual meeting in Chicago held this week. Ethos is an Adaptive Intelligence solution. T...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Source Type: news
Conclusions: Collectively, TSGA10 functional expression alters under the hyper-/hypo-glycemia and hypoxia, which indicates its importance as a candidate bio-target for the cancer therapy. PMID: 31508330 [PubMed]
Source: BioImpacts - Category: Research Tags: Bioimpacts Source Type: research
In conclusion, exposure to luminal neratinib resulted in a pronounced elevation in fluid secretion in the rat intestine. Increasing luminal calcium inhibits the neratinib‐associated fluid secretion in a dose‐dependent manner. These results suggest that CaSR activation may be a potent therapeutic target to reduce chemotherapy‐associated diarrhea.
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract A synthetic, dispersible magnesium aminoclay (MgAC) was synthesized in the present study. Besides, structural and spectroscopic detections were conducted to investigate the MgAC nanoclay. With a poor aqueous solubility, methotrexate (MTX) has been applied as a valid antitumor agent in recent years. In our research, an unobtrusive sol-gel process was carried out to manufacture the MgAC-MTX nanohybrids through entrapment of MTX over MgAC in situ. The final product was capable of desquamating and thus dispersed in water, equably. In comparison with rough MTX, the MgAC-MTX nanocomposite with a preferable trea...
Source: AAPS PharmSciTech - Category: Drugs & Pharmacology Authors: Tags: AAPS PharmSciTech Source Type: research
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