Sphingosine-1-phosphate signaling in blood pressure regulation.

Sphingosine-1-phosphate signaling in blood pressure regulation. Am J Physiol Renal Physiol. 2019 Aug 07;: Authors: Intapad S Abstract Sphingolipids were originally believed to play a role only as a backbone of mammalian cell membranes. However, sphingolipid metabolites, especially sphingosine-1-phosphate (S1P), are now recognized as new bioactive signaling molecules that are critically involved in numerous cellular functions of multiple systems including the immune system, central nervous system, and cardiovascular system. S1P research has accelerated in the last decade as new therapeutic drugs have emerged that target the S1P signaling axis to treat diseases of the immune and central nervous systems. There is limited knowledge of the specific effects on cardiovascular disease. This mini-review discusses the current state of knowledge regarding the role of S1P on the regulation of blood pressure, vascular tone, and renal functions. PMID: 31390266 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research