Trends and risk factors for antimicrobial-resistant Neisseria gonorrhoeae, Melbourne, Australia, 2007 - 2018.

Trends and risk factors for antimicrobial-resistant Neisseria gonorrhoeae, Melbourne, Australia, 2007 - 2018. Antimicrob Agents Chemother. 2019 Aug 05;: Authors: Williamson DA, Fairley CK, Howden BP, Chen MY, Stevens K, De Petra V, Denham I, Chow EPF Abstract Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major public health problem. Traditionally, AMR surveillance programs for N. gonorrhoeae have focused mainly on laboratory data to describe the prevalence and trends of resistance. However, integrating individual-level risk factors (e.g. sexual orientation or international travel) with laboratory data provides important insights into factors promoting the spread of resistant N. gonorrhoeae Here, over a twelve-year period, we assessed the trends and risk factors for resistant N. gonorrhoeae in individuals attending a large publicly-funded sexual health centre in Melbourne, Australia. A total of 7,588 N. gonorrhoeae isolates were cultured from 5,593 individuals between January 1st, 2007 and December 31st, 2018. The proportion of isolates with penicillin resistance decreased from 49.5% in 2007 to 18.3% in 2018 (ptrend<0.001), and from 63.5% in 2007 to 21.1% in 2018 for ciprofloxacin resistance (ptrend<0.001). In contrast, the proportion of isolates displaying decreased susceptibility to ceftriaxone increased from 0.5% in 2007 to 2.9% in 2018 (ptrend<0.001), with a significant increase in low-level azithromycin re...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research