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Kidney grown in lab successfully transplanted into animal

Functioning kidney built from newborn rat cells is a major step towards personalised transplant organs for peopleScientists have grown a kidney in a laboratory and shown that it works when implanted into a living animal. The work is an important step towards the longer-term goal of growing personalised replacement organs that could be transplanted into people with kidney failure.More than 51,000 people are treated every year in the UK for end-stage kidney failure and 90% of those are on the waiting list for organs are waiting for kidneys. A shortage of organs means that every year fewer than 3,000 transplants are carried out, however, while more than 3,000 people die waiting for a transplant.There is no cure for kidney failure. The only available treatments – dialysis or receiving a transplant – just buy a patient more time but come with considerable limitations on quality of life. A patient on dialysis is advised to drink less than a litre of fluid per day, for example. And kidney transplants only last between 10 to 15 years on average, in addition to any complications caused by immune rejection.Finding a new source of replacement organs that could be grown using the patient's own cells and that could last a lifetime would, therefore, be a big leap forward.In the latest work, Harald Ott of Massachusetts General hospital led a team of scientists who grew a kidney by using an experimental technique that has previously been used to create working hearts, lungs and l...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Tissue engineering World news Health guardian.co.uk Medical research Society UK news Science Source Type: news

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In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study aimed to evaluate the impact of donor HTN on patient survival of SLKT recipients and to identify independent risk factors. MATERIAL AND METHODS Data from 3844 adult SLKT recipients receiving deceased donor grafts from March 2002 to December 2014 in the Scientific Registry of Transplant Recipients (SRTR) database were retrospectively analyzed. Kaplan-Meier analysis was used to compare patient and graft survival. Multivariate Cox proportional hazard models were built to identify independent risk factors associated with patient and graft survival. RESULTS SLKT patients receiving HTN donor grafts had significantly s...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
The week of April 23-27 has been designated as National Pediatric Transplant Week.  This week is to bring attention to the great need for organ donations and to honor  donors and their families whose incredibly selfless gift has given someone the gift of life.While most of us will never experience the need for a transplant, there are many of us who know someone who has a debilitating condition such as kidney dialysis that are in need of a transplant.Right now there are almost 2,000 children on the national transplant list.  Those needing hearts, lungs, eyes, tissue, liver, kidney, or some other body part are...
Source: Pediatric Health Associates - Category: Pediatrics Tags: Volunteer Opportunities Source Type: news
Conditions:   Medication Adherence;   Kidney Transplant Intervention:   Other: mHealth Intervention Sponsor:   Johns Hopkins University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
COPENHAGEN, Denmark, April 20, 2018 -- (Healthcare Sales &Marketing Network) -- Veloxis Pharmaceuticals A/S announced today that the U.S. Food &Drug Administration (FDA) has accepted for standard review the Company's supplemental New Drug Application (s... Biopharmaceuticals, FDA Veloxis Pharmaceuticals, ENVARSUS, tacrolimus, kidney transplant
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
Abstract Organ shortage has long been an obstacle to transplant procedures. As acceptance of aging kidneys from expanded criteria donors increases, the long-term outcomes of renal allografts could be unsatisfactory. The klotho gene, which is known as an antiaging gene that is highly expressed in kidneys, is closely associated with chronic kidney disease and acute kidney injury. Results from existing literature have shown a tendency to support Klotho as a renal protective protein owing to its pleiotropic effects. However, few data are available on Klotho in renal transplant. Whether Klotho serves the same purposes ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
American Journal of Transplantation, EarlyView.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Source Type: research
AbstractPurpose of reviewOrgan transplantations often include major incisions that can be associated with significant postoperative pain. While these patients may theoretically benefit from regional anesthesia, many practitioners have avoided such techniques due to considerations, such as a low perceived benefit if the patient stays intubated postoperatively and concerns about the coagulation status in patients with end-stage liver/kidney disease and perioperative use of anticoagulation.Recent findingsWith refinements in both surgical (laparoscopic and robot-assisted procedures) and regional anesthesia techniques (ultrasou...
Source: Current Anesthesiology Reports - Category: Anesthesiology Source Type: research
Pediatric Transplantation, EarlyView.
Source: Pediatric Transplantation - Category: Transplant Surgery Authors: Source Type: research
ConclusionsIn the past decade, the incidence of dialysis has stabilized in both the general population and in diabetics in whom it remains far higher by comparison. Also mortality rates are higher, with a worse prognosis for T1DM. Diabetes poses a barrier to allotransplantation, and efforts should be made to overcome this limitation.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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