Kidney grown in lab successfully transplanted into animal

Functioning kidney built from newborn rat cells is a major step towards personalised transplant organs for peopleScientists have grown a kidney in a laboratory and shown that it works when implanted into a living animal. The work is an important step towards the longer-term goal of growing personalised replacement organs that could be transplanted into people with kidney failure.More than 51,000 people are treated every year in the UK for end-stage kidney failure and 90% of those are on the waiting list for organs are waiting for kidneys. A shortage of organs means that every year fewer than 3,000 transplants are carried out, however, while more than 3,000 people die waiting for a transplant.There is no cure for kidney failure. The only available treatments – dialysis or receiving a transplant – just buy a patient more time but come with considerable limitations on quality of life. A patient on dialysis is advised to drink less than a litre of fluid per day, for example. And kidney transplants only last between 10 to 15 years on average, in addition to any complications caused by immune rejection.Finding a new source of replacement organs that could be grown using the patient's own cells and that could last a lifetime would, therefore, be a big leap forward.In the latest work, Harald Ott of Massachusetts General hospital led a team of scientists who grew a kidney by using an experimental technique that has previously been used to create working hearts, lungs and l...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Tissue engineering World news Health guardian.co.uk Medical research Society UK news Science Source Type: news

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The week of April 23-27 has been designated as National Pediatric Transplant Week.  This week is to bring attention to the great need for organ donations and to honor  donors and their families whose incredibly selfless gift has given someone the gift of life.While most of us will never experience the need for a transplant, there are many of us who know someone who has a debilitating condition such as kidney dialysis that are in need of a transplant.Right now there are almost 2,000 children on the national transplant list.  Those needing hearts, lungs, eyes, tissue, liver, kidney, or some other body part are...
Source: Pediatric Health Associates - Category: Pediatrics Tags: Volunteer Opportunities Source Type: news
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: Peritoneal dialysis appears to be an effective replacement therapy for patients with a previous history of solid-organ transplantation. PMID: 29162679 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, we found that IS status was associated with a significant increase in Hannum DNA methylation, likely as a consequence of the accumulation of cardiovascular risk factors, and near signification with Horvath method. Patients with IS were biologically older than controls, a difference that was more obvious in young stroke. This could open up the possibility of useful new biomarker of stroke risk. Latest Headlines from Fight Aging! A Profile of Kelsey Moody and Ichor Therapeutics https://www.fightaging.org/archives/2016/09/a-profile-of-kelsey-moody
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
An organ transplant is a life-changing event extending far beyond the operating room, the clinics and the hospital walls. Read about five children, one young adult and their families, whose lives were forever changed by the Pediatric Transplant Center at Boston Children’s Hospital. Lydia’s liver transplant, a mom’s gift Dawn Cavanagh gave her daughter life twice — first when she was born and, again, when she gave 13-year-old Lydia a piece of her liver last summer. The donor-approval process, which occurs with Boston Children’s partner Lahey Hospital &Medical Center, required hours of...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Our Patients’ Stories double lung transplant ECMO heart failure heart transplant Heart transplant program heart-lung transplant Heung Bae Kim Intestine and Multivisceral Transplant Program Khashayar Vakili kidney transplant Kidney Source Type: news
There’s something you should know about chronic kidney disease. Most doctors will tell you there is no alternative treatments for kidney problems besides costly dialysis or a transplant to deal with impaired renal function. What Is Kidney Failure? Kidney dialysis is a treatment that uses a special machine to filter harmful wastes, salt and excess from your blood. But there is another option. It’s called stem cell biotherapy, and it offers new hope to those with this life-threatening disease. You may think your kidneys are just fine and you have nothing to worry about. But consider this… What Causes Kidn...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
Organ transplantation saves lives. Once considered a last resort for critically ill patients, it is now a practical treatment for freeing kidney patients from dialysis machines and giving patients dying from heart, liver, lung and pancreatic disease a second chance for life. Unfortunately, the number of human organs available for transplantation has never been sufficient to meet the need. Many transplant candidates die waiting for an organ that does not come. The 2006 revision of the Uniform Anatomical Gift Act (UAGA) was an attempt to legislatively find a way to alleviate this shortage.
Source: Value in Health - Category: Global & Universal Authors: Source Type: research
This is the season for gratitude and giving, a time to celebrate friends, family, the end of one year and the beginning of a new one. But for a select group, it also is a time to celebrate one of the greatest gifts — the gift of life through organ donation. Mickey was born with a unique combination of congenital heart defects and spent most of his early life at Boston Children’s. He was one day shy of 6 months old when he received his heart transplant, and his family is grateful for every day since. “Mickey has shown us what courage and resiliency look like, and his transplant has taught us the true mean...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories double lung transplant heart transplant hepatoblastoma kidney transplant Liver transplant multivisceral transplant Pediatric Transplant Center (PTC) Source Type: news
Conclusion: there is no increased risk of doing the lymph node dissection early on.   Dr. Eggener-CON   Basics Lymph node dissections rarely done, even for large tumors, because there is no proven therapeutic or staging benefit for low risk patients.  A Mayo study revealed no data showing therapeutic benefit in high risk patients.  For clinically node negative high risk patients, there is staging value but no proven therapeutic benefit. Rate of positive nodes is associated with stage and grade; the higher the stage and grade, the more likely there will be positive nod...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
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