Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms

ConclusionsThe combined drug treatment with glucose produced a large acute CEST MRI contrast indicating tumor acidification, which could be used to help localize brain cancer and monitor tumor response to chemotherapy.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Conclusion: The positive and negative points of the image-based cell models and computergenerated cell models some scientific advices are presented in this work. Generally, the imagebased cell models could offer analytical facts for each state, but they are expensive and timeconsuming; besides, their performance is heavily influenced by deformation techniques. The computer-generated cell model, on the other hand, provides a higher cost of production and simplicity, but its main contribution is the overall performance and accuracy.
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
ConclusionsExisting literature suggests that the application of radiation chronotherapy may reduce negative symptom outcome within highly proliferative tissues. Further examination of radiation chronotherapy in well-designed prospective trials and studies in brain tumor patients are merited.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
This study suggests that features of Tuberous sclerosis especially when overlapping with those of Neurofibromatosis 1 or malignancies atypical for these syndromes should raise the possibility of constitutional mismatch repair deficiency. Correct diagnosis is essential for appropriate genetic counselling and pre-emptive cancer surveillance. This article is protected by copyright. All rights reserved. PMID: 31730237 [PubMed - as supplied by publisher]
Source: Clinical Genetics - Category: Genetics & Stem Cells Authors: Tags: Clin Genet Source Type: research
Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. Despite multimodal treatment regimens, median survival in unselected patient cohorts is
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Inhaling combustion-produced particles may lead to the development of brain tumors.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
(Karolinska Institutet) Children who have received radiotherapy for a brain tumor can develop cognitive problems later in life. In their studies on mice, researchers at Karolinska Institutet have now shown that the drug lithium can help to reverse the damage caused long after it has occurred. The study is published in the journal Molecular Psychiatry and the researchers are now planning to test the treatment in clinical trials.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This Medical News article discusses recent developments in neurology and neuroscience related to glioma progression, immunizations and multiple sclerosis, and deep brain stimulation for tinnitus.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
Abstract Glioblastoma is a highly aggressive and invasive brain tumor. Current treatment options do not prolong overall survival significantly because the disease is highly prone to relapse. Therefore, research to find new therapies is of paramount importance. It was discovered that glioblastomas contain a population of cells with stem-like properties and that these cells are may be responsible for tumor recurrence. In this critical review, we will discuss potential treatment strategies to target cancer stem cells in glioblastoma with the focus on clinical perspectives. Several fundamental issues related to the re...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
AbstractAnnually, the incidence of brain tumors has slightly increased and also the patient prognosis is still disappointing, especially for high-grade neoplasms. So, researchers seek methods to improve therapeutic index as a critical aim of treatment. One of these new challenging methods is radioimmunotherapy (RIT) that involves recruiting a coupling of radionuclide component with monoclonal antibody (mAb) which are targeted against cell surface tumor –related antigens or antigens of cells within the tumor microenvironment. In the context of cancer care, precision medicine is exemplified by RIT; precision medicine c...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Daria Riva Neurofibromatosis type-1 (NF1) is a monogenic tumor-predisposition syndrome creating a wide variety of cognitive and behavioral abnormalities, such as decrease in cognitive functioning, deficits in visuospatial processing, attention, and social functioning. NF1 patients are at risk to develop neurofibromas and other tumors, such as optic pathway gliomas and other tumors of the central nervous system. Few studies have investigated the impact of an additional diagnosis of brain tumor on the cognitive outcome of children with NF1, showing unclear results and without controlling by the effect of surgery, radio-...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
More News: Acetazolamide | Brain | Brain Cancers | Brain Tumor | Cancer | Cancer & Oncology | Chemistry | Chemotherapy | MRI Scan | Neurology | Pantoprazole | PET Scan | Protonix | Study