Utility of measuring tryptase levels in children and young adults

Tryptase is produced primarily by mast cells. Mast cell degranulation results in release of tryptase and anaphylaxis may result in elevated tryptase levels, with return to normal levels over a few hours.1 Persistent or episodic elevation of tryptase levels can be indicative of increased body mast cell burden or mast cell activation, typically seen in mastocytosis and mast cell activation disorder (MCAD).2 Elevated serum tryptase levels represent a significant risk factor for severe anaphylaxis to hymenoptera stings.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research