Evaluating RANKL and OPG levels in patients with Duchenne muscular dystrophy

ConclusionThere was significant decline in RANKL, OPG, and RANKL:OPG with age in DMD patients compared with controls, potentially due to disease severity or worsening osteoblastic function. This suggests some bone turnover markers may be difficult to assess or use as therapeutic indicators in DMD patients. Larger studies are needed to evaluate the role of RANKL-OPG in DMD patients to provide better targeted therapy.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research