Restricted myeloperoxidase epitopes drive the adaptive immune response in MPO-ANCA vasculitis.

CONCLUSIONS: These observations reveal interactions between restricted MPO epitopes and the adaptive immune system within ANCA vasculitis that may inform new antigen-specific therapies in autoimmune disease while providing insight into immunopathogenesis. PMID: 31383567 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31383567?dopt=Abstract

Source: Journal of Autoimmunity - August 1, 2019 Category: Allergy & Immunology Authors: Free ME, Stember KG, Hess JJ, McInnis EA, Lardinois O, Hogan SL, Hu Y, Mendoza C, Le AK, Guseman AJ, Pilkinton MA, Bortone DS, Cowens K, Sidney J, Karosiene E, Peters B, James E, Kwok WW, Vincent BG, Mallal SA, Jennette JC, Ciavatta DJ, Falk RJ Tags: J Autoimmun Source Type: research