Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study

ConclusionsAge-related changes in pharmacokinetics of 4-methylaminoantipyrine requires reduced weight –based IV dosing in infants<  1 year compared with infants and children up to 6 years (5 versus 10–20 mg/kg) to achieve equivalent adult exposure.Trial registrationClinicalTrials.gov identifier:NCT02660177.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research