Cotard-syndrome associated with Hashimoto encephalopathy: a case report.

[Cotard-syndrome associated with Hashimoto encephalopathy: a case report]. Neuropsychopharmacol Hung. 2019 Jun;21(2):85-93 Authors: Hajnal L, Lazary J Abstract There is a growing body of data on encephalopathy-related psychiatric syndromes in the literature, however, clinical management of them still remains a great challenge. Although organic background of the rarely identified Cotard-syndrome has been reported in numerous pathological states, Hashimoto-encephalopathy has not been published in association with this clinical phenotype so far. In this paper we present a case of a 44 year old woman, who previously never had a psychiatric disorder and her clinical symptoms corresponded to Cotard II syndrome. She produced psychotic depression with nihilistic doxasmas related to shutting down, clogging and rotting of her organs. These psychiatric symptoms were accompanied by cognitive, motor and vegetative signs, therefore we systematically excluded all organic brain disorders described in the literature. Besides the bizarre mental symptoms we found significantly increased anti-TPO levels in her serum, aspecific pathological signs on scull MR scans and thyreoid disease in the medical history. After differential diagnostic analyses we diagnosed Hashimoto-encephalopathy (HE), which was confirmed by positive clinical response to steroid therapy. Certain forms of HE (also named as steroid-responsive encephalopathy associated with autoimmune thyreoiditis, SREAT) ar...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research

Related Links:

AbstractHypothyroidism affects up to 5% of the general population, with a further estimated 5% being undiagnosed. Over 99% of affected patients suffer from primary hypothyroidism. Worldwide, environmental iodine deficiency is the most common cause of all thyroid disorders, including hypothyroidism, but in areas of iodine sufficiency, Hashimoto ’s disease (chronic autoimmune thyroiditis) is the most common cause of thyroid failure. Hypothyroidism is diagnosed biochemically, being overt primary hypothyroidism defined as serum thyroid-stimulating hormone (TSH) concentrations above and thyroxine concentrations below the ...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Abstract Evaluation of Seizure Treatment in Anti-LGI1, Anti-NMDAR, and Anti-GABABR Encephalitis de Bruijn MAAM, van Sonderen A, van Coevorden-Hameete MH, Bastiaansen AEM, Schreurs MWJ, Rouhl RPW, van Donselaar CA, Majoie MHJM, Neuteboom RF, Sillevis Smitt PAE, Thijs RD, Titulaer MJ. Neurology. 2019;92(19): e2185-e2196. doi:10.1212/WNL.0000000000007475. Epub April 12, 2019. PMID: 30979857 OBJECTIVE: This nationwide cohort study evaluates seizure responses to immunotherapy and antiepileptic drugs (AEDs) in patients with anti-leucine-rich glioma-inactivated 1 (LGI1), anti-NMDA receptor (NMDAR), and anti-gamma-aminobu...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Epilepsy Curr Source Type: research
Importance: Alopecia areata (AA) is an autoimmune disease characterized by hair loss. It can impose substantial psychological burden to patients including major depressive disorder (MDD), yet many patients report mental health symptoms prior to AA onset. As such, there may be a relationship between MDD and AA that acts in both directions.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Abstract Immune-mediated inflammation of the brain has been recognized for more than 50 years, although the initial descriptions were mainly thought to be secondary to an underlying neoplasm. Some of these paraneoplastic encephalitides express serum antibodies, but these were not thought to be pathogenic but instead have a T-cell-mediated pathophysiology. Over the last two decades, several pathogenic antibodies against neuronal surface antigens have been described in autoimmune encephalitis, which are amenable to immunotherapy. Several of these antibodies are directed against glutamate receptors (GluRs). NMDA...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
This study raises the possibility of a role for surgery for patients with Hashimoto’s thyroiditis who continue to feel poorly despite optimal treatment with thyroid hormone. However, the study, while well done, is a relatively small one. We need longer-term follow up and confirmation with additional studies done on diverse populations. It’s also important to consider that thyroid surgery in patients with advanced Hashimoto’s thyroiditis is difficult. Rates of complications, including injury to the laryngeal nerve (which controls voice) and the parathyroid glands (which maintain normal blood calcium levels...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Thyroid Disorders Source Type: blogs
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
The prevalence of depression is higher in individuals suffering from autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the Major Histocompatibility Complex (MHC), which is associated with risk for autoimmune diseases, is also associated with risk for depression.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research
Publication date: Available online 3 August 2019Source: Pediatric Dental JournalAuthor(s): Setsuyo Morimoto, Keiko Hirano, Keiko Tabata, Haruka Asaumi, Yuko Morikawa, Yuki Matsumi, Shuhei Naka, Michiyo Matsumoto-NakanoAbstractEarly onset periodontitis is rarely seen in infants, though often leads to an acute and serious clinical course when encountered in such patients. Autoimmune neutropenia presents systemic and dental symptoms, as depressed resistance to bacterial infection is caused by a disorder that reduces the number of neutrophils. This disease can result in not only gingival inflammation but also destruction of pe...
Source: Pediatric Dental Journal - Category: Dentistry Source Type: research
CONCLUSION: This cross-sectional study suggested that body image-related quality of life may mediate the effects of pain on depressive symptoms among patients with SLE. PMID: 31369342 [PubMed - in process]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
AbstractIntroduction/objectivesPrimary Sj ögren’s syndrome (pSS) is a chronic systemic autoimmune disease. The aim of this study was to investigate the risk of five common psychiatrist-diagnosed disorders in patients with pSS.MethodUsing Taiwan ’s National Health Insurance Research Database, 688 patients with newly diagnosed pSS between 2000 and 2012 were identified. Two comparison cohorts were assembled, namely, 3440 patients without pSS and 1302 newly diagnosed patients with rheumatoid arthritis. The incidences of depressive disorder, anxiety disorder, bipolar disorder, sleep disorder, and schizophrenia ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
More News: Autoimmune Disease | Brain | Depression | Men | Neurology | Organic | PET Scan | Psychiatry | Steroid Therapy