Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion [Physiology]

Membrane transporters and receptors are responsible for balancing nutrient and metabolite levels to aid body homeostasis. Here, we report that proximal tubule cells in kidneys sense elevated endogenous, gut microbiome-derived, metabolite levels through EGF receptors and downstream signaling to induce their secretion by up-regulating the organic anion transporter-1 (OAT1). Remote...

Source: Proceedings of the National Academy of Sciences - August 5, 2019 Category: Science Authors: Jitske Jansen, Katȷa Jansen, Ellen Neven, Ruben Poesen, Amr Othman, Alain van Mil, Joost Sluiȷter, Javier Sastre Torano, Esther A. Zaal, Celia R. Berkers, Diederik Esser, Harry J. Wichers, Karin van Ede, Maȷorie van Duursen, Stephane Tags: Biological Sciences Source Type: research