Weight loss jab dubbed 'most exciting obesity treatment yet' helps patients lose 10lbs in a month

The jab, developed by Imperial College London, was tested on 15 patients. It contains three hormones that mimic the effects of a gastric bypass surgery.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusion: Based on this study, 180-cm intestinal bypassed length works for patients with a BMI level of 40-45 and 45-50 kg/m2, according to their significant decrease in weight, BMI, and improving glycolipid profile. PMID: 32257428 [PubMed - as supplied by publisher]
Source: Journal of Obesity - Category: Eating Disorders & Weight Management Tags: J Obes Source Type: research
AbstractPurposeThe utility of available scoring systems for type 2 diabetes (T2D) remission prediction after metabolic surgery has not been defined in a multi-ethnic Asian population like Singapore. We sought to assess the predictive performance of the Asia-developed ABCD scoring system for T2D remission after metabolic surgery, and develop a new algorithm to improve prediction.Materials and MethodsWe conducted a retrospective analysis of adults with T2D who underwent either Roux-en-Y gastric bypass or sleeve gastrectomy between 2007 and 2018, and followed for 1  year postoperatively (n = 114, mean age 4...
Source: Obesity Surgery - Category: Surgery Source Type: research
We present a video of a patient who suffered both early Roux limb obstruction, and late Petersen ’s hernia with proximal biliopancreatic limb volvulus and gangrene up to the ligament of Treitz, and how both were managed.
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsConversion of a failed LAGB to OAGB is effective but carries higher complication rates. Randomized controlled studies comparing different procedures are necessary to further clarify the optimal revisional bariatric operation.
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractIntroductionBone mineral density (BMD) declines in the initial years after bariatric surgery, but long-term skeletal effects are unclear and comparisons between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are rare.Design and MethodsAn observational longitudinal study of obese patients undergoing SG or RYGB was performed. Whole-body (WB) BMD, along with BMD of the total hip (TH), femoral neck (FN), and lumbar spine (LS), was measured by dual-energy X-ray absorptiometry (DXA) before surgery and yearly thereafter for 4  years. Calciotropic hormones were also measured.ResultsForty-seven patients un...
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsThis is the first report of cognitive improvements following VSG and the first direct comparison of cognitive improvements following RYGB and VSG. Short-term improvements in specific domains of cognitive function are observed at the beginning of the active weight loss phase following bariatric surgery that persisted to 3  months. The anatomical distinction between the two surgeries and resulting differential metabolic profiles may be responsible for the improvements in attention observed following RYGB but not following VSG.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
As recently summarized1, there are only four randomized clinical trials (RCTs) in patients with type 2 diabetes mellitus (T2DM) comparing Roux-en-Y gastric bypass (RYGB) with sleeve gastrectomy (SG) and providing level I evidence up to 5 years after randomization.2-5 None of the individual studies were primarily designed and adequately powered to compare the effects of RYGB with SG on T2DM. However, combined analysis of these RCTs (i.e. meta-analysis) in order to increase the sample size and statistical power (RYGB, n=176 versus SG, n=175) would indicate that either there is no significant long-term difference between RYGB...
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
ConclusionsIn patients aged 40 ‐65, gastric bypass but not sleeve gastrectomy or the other procedures increased risk of major osteoporotic fractures.This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
In the current manuscript (1) the authors reported the results of diagnostic upper endoscopy for a cohort of 250 consequent patients who presented with complaints after Roux en Y gastric bypass (RYGB). Ninety-eight patients (39.2%) with a relevant finding at upper endoscopy were identified, mostly marginal ulcer and stomal stenosis. The postoperative endoscopic findings can help us better understand long term complications following bariatric surgery. The authors should be commended for identifying risks factors to an abnormal upper endoscopy (male sex, smoking, alcohol consumption, referral reason and prior imaging studies).
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
Roux-en-O anatomy after Roux-en-Y gastric bypass (RYGB) is a rare and potentially devastating complication that can be frequently misdiagnosed 1,2. Generally, the biliopancreatic limb is inadvertently anastomosed to the gastric pouch and patients may present as a partial small bowel obstruction with most frequent complaint of abdominal pain, nausea, and bilious emesis. Radiologic studies and even surgical exploration may misdiagnose this atypical complication3,4.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: VIDEO CASE REPORT Source Type: research
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