PTTG1 is involved in TNF ‐α‐related hepatocellular carcinoma via the induction of c‐myc

Our data suggest that pituitary tumor transforming gene 1 (PTTG1) plays a vital role in inflammation ‐related hepatocellular carcinoma (HCC) via c‐myc induction and that PTTG1 may be a potential therapeutic target for HCC. AbstractHepatocellular carcinoma (HCC) is a malignant disease caused by a variety of factors. However, the genomic and molecular aberrations in HCC are largely unknown. Herein,pituitary tumor transforming gene 1 (PTTG1) was discovered as a potential inflammation ‐related oncogene in HCC, and its functions and molecular mechanisms were investigated. mRNA expression microarray, real‐time polymerase chain reaction (PCR), immunohistochemistry, and western blotting analyses revealed thatPTTG1 is upregulated in HCC. Further in vitro and in vivo studies indicated that the proinflammatory cytokine tumor necrosis factor ‐α (TNF‐α) inducesPTTG1 expression, and PTTG1 was found to upregulate c ‐myc, a well‐known oncogene. Downregulation of PTTG1 reduced c‐myc and proliferating cell nuclear antigen (PCNA) expression and inhibited cell proliferation. Interestingly, inhibition of c‐myc by 10058‐F4 did not affect PTTG1, which suggests that PTTG1 regulates c‐myc expression. Furthe rmore, PTTG1 expression levels are inversely correlated with HCC patient survival, indicating an independent prognostic biomarker for patients with HCC. Our data demonstrate that PTTG1 is involved in TNF‐α‐related HCC via c‐myc induction and tha...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Authors: Cao M, Zhou M, Zhang J Abstract Patients with metastatic colorectal cancer (mCRC) beyond second line treatment have a poor prognosis. Regorafenib, TAS-102, fruquintinib, panitumumab and cetuximab are recommended single-agent chemotherapy regimens for patients exhibiting disease progression, this meta-analysis aimed to evaluate the efficacy and safety of these regimens in randomized controlled trials (RCTs). Eight RCTs with 3,832 cancer patients were included. Results showed that there was no significant difference in OS and PFS among the four drugs when comparing all patients or patients who have the KRAS ...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
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Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
In this study, dosimeters were used to measure the testicular dose with and without testicular shielding to verify the effect of shielding. Anthropomorphic phantoms representing a human were used to estimate the doses absorbed in testicular and whole-body studies. The anthropomorphic phantom was irradiated according to the treatment protocol for colorectal cancer. Measurements were made using optically-stimulated luminescent dosimeters (OSLDs), composed of carbon-doped aluminum oxide, with characteristics suitable for radiotherapy dosimetry studies. A set of OSLDs was placed on a testicular phantom, attached to the lower e...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
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Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Immunology Source Type: research
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Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Authors: Hessam S, Bechara FG Abstract Hidradenitis suppurativa/acne inversa (HS/AI) is a chronic inflammatory skin disease. Several studies showed that perianal, perineal and gluteal involvement is more common in men. Axillary, submammary and inguinal localizations seem to be more prevalent in women. Involvement of the genitoanal region is associated with a higher reduced quality of live and sexual health compared to other locations. Moreover HS/AI in the genitoanal region can lead to serious complications. The knowledge of perianal fistula formation, pubogenital lymphedema and squamous cell carcinoma, w...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Ivana Bjelobaba1,2, Marija M. Janjic1,2, Rafael Maso Prévide1, Daniel Abebe1, Marek Kucka1 and Stanko S. Stojilkovic1* 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, United States 2Institute for Biological Research Sinisa Stankovic, University of Belgrade, Belgrade, Serbia Cell-matrix interactions play important roles in pituitary development, physiology, and pathogenesis. In other tissues, a family of non-collagenous proteins, termed SIBLINGs, are known to contribute to cell-matrix interactions. Anterior pituitary gland...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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