RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay

RNA modifications exert important effects in many critical physiological processes. Using RNA-BisSeq, Yang et  al. provide a comprehensive view of the RNA m5C landscape in zebrafish early embryos and show that m5C-modified maternal mRNAs are stabilized by Ybx1 and Pabpc1a during zebrafish MZT.

Source: Molecular Cell - August 5, 2019 Category: Cytology Authors: Ying Yang, Lu Wang, Xiao Han, Wen-Lan Yang, Mengmeng Zhang, Hai-Li Ma, Bao-Fa Sun, Ang Li, Jun Xia, Jing Chen, Jian Heng, Baixing Wu, Yu-Sheng Chen, Jia-Wei Xu, Xin Yang, Huan Yao, Jiawei Sun, Cong Lyu, Hai-Lin Wang, Ying Huang, Ying-Pu Sun, Yong-Liang Zh Tags: Article Source Type: research