Burden of typical diseases attributed to the sources of PM2.5-bound toxic metals in Beijing: An integrated approach to source apportionment and QALYs.

Burden of typical diseases attributed to the sources of PM2.5-bound toxic metals in Beijing: An integrated approach to source apportionment and QALYs. Environ Int. 2019 Aug 01;131:105041 Authors: Liu J, Chen Y, Cao H, Zhang A Abstract PM2.5-bound toxic metals (TMs) are derived from various sources, and they can cause many adverse health effects on the human body. To effectively reduce the disease burden of TMs by controlling the relative sources, an integrated approach of quality-adjusted life years (QALYs) and source-apportionment (positive matrix factorization, PMF) was proposed and applied to some typical diseases induced by TMs in 2017 in Beijing. The estimation included two parts; first, the number of potentially affected people was calculated based on the source mass contribution from PMF and the inhalation unit risk of TMs; second, the QALYs lost per affected person was calculated based on the disease duration, expected years of life lost (EYLL) and quality of life (QoL) for both affected people and the general population. The results showed that QALYs lost per person for renal cancer (17.3 QALYs), pneumonia (14.4 QALYs), lung cancer (14.2 QALYs), skin cancer (12.7 QALYs) and diabetes mellitus (12.6 QALYs) were higher than those for other diseases. Combined with PMF, the source contributions to the overall burden of typical diseases from the TMs followed the order of coal combustion (50.2%) > vehicle emissions (24.4%)â€...
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research