Frontal crash simulations using parametric human models representing a diverse population.

Conclusions: This study is the first to use a large set of diverse FE human models to investigate the combined effects of age, sex, stature, and BMI on injury risks in frontal crashes. The study demonstrated that parametric human models can effectively predict the injury trends for the population and may now be used to optimize restraint systems for people who are not similar in size and shape to the available anthropomorphic test devices (ATDs). New restraints that adapt to occupant age, sex, stature, and body shape may improve crash safety for all occupants. PMID: 31381451 [PubMed - in process]
Source: Traffic Injury Prevention - Category: Accident Prevention Authors: Tags: Traffic Inj Prev Source Type: research

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Abstract A synthetic monomeric peptide triple receptor agonist, termed "Triagonist" that incorporates glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (Gcg) actions, was previously developed to improve upon metabolic and glucose regulatory benefits of single and dual receptor agonists in rodent models of diet-induced obesity and type 2 diabetes. In the current study, the neurotrophic and neuroprotective actions of this Triagonist were probed in cellular and mouse models of mild traumatic brain injury (mTBI), a prevalent cause of neurodegeneration in both th...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
Dominic Oliver1,2, Joaquim Radua1,3,4, Abraham Reichenberg5,6,7,8, Rudolf Uher9 and Paolo Fusar-Poli1,2,10,11* 1Early Psychosis: Interventions and Clinical Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom 2OASIS Service, South London and the Maudsley NHS Foundation Trust, London, United Kingdom 3Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain 4Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockh...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study used the data from Nationwide Inpatient Sample database for the years 2002-2012 to identify patients with vena caval filter placement. Trends in both therapeutic and prophylactic vena caval filter use over the eleven year period were analyzed. Multiple simple logistic regression model was used to assess trends. Results The overall incidence of vena caval filter placement increased from 2002 to 2012. The odds of vena caval filter placement in 2012 were 1.340 (95% CI: 1.236, 1.453) times the odds of vena caval filter placement in 2002. However, a downward trend was observed after the year 2010. The odds of vena ca...
Source: Reviews on Recent Clinical Trials - Category: Cancer & Oncology Authors: Tags: Rev Recent Clin Trials Source Type: research
We examined the cross-sectional association between taste and smell dysfunction and blood cholesterol concentrations. Methods: With the use of a questionnaire, we assessed chronic smell and taste dysfunction in 12,627 Chinese participants (10,418 men and 2209 women; mean age: 54.4 y) who did not take hypolipidemic agents. Participants were categorized into 3 groups based on the number of smell and taste dysfunctions, ranging from 0 (best) to 2 (worst). A general linear model was used to test differences in serum concentrations of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides (TGs) across groups wit...
Source: Journal of Nutrition - Category: Nutrition Authors: Tags: Nutritional Epidemiology Research Articles Source Type: research
ObjectivesThe pathophysiology of bipolar disorder is likely to involve both genetic and environmental risk factors. In our study, we aimed to perform a systematic search of environmental risk factors for BD. In addition, we assessed possible hints of bias in this literature, and identified risk factors supported by high epidemiological credibility. MethodsWe searched the Pubmed/MEDLINE, EMBASE and PsycInfo databases up to 7 October 2016 to identify systematic reviews and meta‐analyses of observational studies that assessed associations between putative environmental risk factors and BD. For each meta‐analysis, we estim...
Source: Bipolar Disorders - Category: Psychiatry Authors: Tags: REVIEW ARTICLE Source Type: research
Disruptive technologies are taking huge leaps towards revolutionizing whole areas, also in medicine and healthcare, while we are way behind in understanding how they function and what effect they have on us. I believe we have to get used to these technologies which might turn out to be very scary at first, or even at second sight. I cannot wait to stop wasting my time driving cars and focus on my work while my automated vehicle takes me wherever I need to go. But I’m sure I’m going to be nervous in the first few dozens of trips and I will keep my eyes on the road. Disruptive technologies take time to get comfor...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine AI artificial intelligence augmented reality exoskeletons food scanner GC1 genomics Healthcare Innovation robotics technology virtual reality Source Type: blogs
A 66-year-old overweight insulin-dependent male passenger with diabetes and severe arthritis was on a 4-week circle-Pacific cruise. He fell ashore and hit his head. The ship was about to leave on a non-stop voyage - without any evacuation possibilities for...
Source: SafetyLit - Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Conclusion This is an important study, but the more alarming headlines over-state the absolute risks of problems in adulthood following on from a childhood head injury. The majority of people who'd had a head injury didn't have any of the problems studied, and the overall risk of death by age 41 – the outcome that got most press attention – was 1.6% – only 0.2 percentage points higher than for the unaffected siblings of children with head injury. The study has a number of strengths: it is very large has a long follow-up period the Swedish database records are thought to be accurate it includes fig...
Source: NHS News Feed - Category: Consumer Health News Tags: Neurology Mental health Pregnancy/child Source Type: news
Conclusions The study concluded that PD with 67.71 (per 100,000) of prevalence rate can be associated with several risk factors such as male gender, genetic history, head injury/trauma, type-2 diabetes, Alzheimer's disease, depression and blood pressure among the populations of North India.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
This study ignores important and powerful evidence supporting the safe use of swaddling (and the risks of not swaddling). In 2014, the Journal of Pediatrics published the most comprehensive study of swaddling-related sleep deaths ever done in the U.S. It reviewed eight years of all swaddle-related deaths reported to the federal Consumer Product Safety Commission (CPSC). Fewer than three deaths per year were reported among swaddled babies. Only one death was reported over that extensive period of a baby who was swaddled in a blanket and placed on the back. In fact, that study's authors stressed the safety of swaddling by n...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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