Man who received nation's first 'breathing lung' transplant at UCLA thankful for gift of life

  Fernando Padilla could barely breathe or walk more than a few steps. An incurable disease, pulmonary fibrosis, was causing his lungs to turn to hardened scar tissue, and he was permanently tethered to an oxygen tank. His only hope was a double lung transplant.   In November 2012, he got an early-morning call that a pair of donor lungs was available.   Upon arriving at Ronald Reagan UCLA Medical Center, he was told of a new study testing an experimental device — a portable organ-preservation system that keeps donor lungs functioning and "breathing" in a near-physiologic state outside the body during transport to a recipient, instead of the standard method, in which the organs are kept in an icebox in a non-functioning, non-breathing state.    Padilla consented to participate in the study and was randomized to become the first patient at UCLA — and in the United States — to undergo the 'breathing lung' transplant using the TransMedics Organ Care System (OCS).   "If they've got new technology to deliver the lungs still breathing, I think that would be better than trying to wake them back up again after being on ice," said the former construction worker, who had helped build the very same hospital where he was now a patient. "I'm just following technology."   With the OCS, the lungs are removed from a donor's body and are placed in a mobile high-tech box, where they are immediately revived to a w...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Intrauterine growth restriction (IUGR) is estimated to occur in 5% of pregnancies, with placental insufficiency being the most common cause in developed countries. While it is known that white matter injury occurs in premature infants, the extent of IUGR on white matter injury is less defined in term infants. We used a novel murine model that utilizes a thromboxane A2 (TXA2) analog (U46619), a potent vasoconstrictor, to induce maternal hypertension and mimic human placental insufficiency-induced IUGR to study the white matter. We also investigated the role of hyperoxia as an additional risk factor for white matter injury, ...
Source: Developmental Neuroscience - Category: Neuroscience Source Type: research
Conclusions:Unrecognized severe OSA was common in patients with difficult-to-control hypertension, and OSA severity was associated with myocardial injury, independent of BP control with medications.Clinical Trial Registration:Registry:, Title: A Cross-sectional Study of the Occurrence and Effect of Obstructive Sleep Apnea in Subjects With Resistant Hypertension, Identifier: NCT00843583, URL: MM, Tse HF, Mak JC, Lam DC, Chan CW, Chong PW, Ip MS. Untreated obstructive sleep apnea is associated with myocardial injury independent of blood pressure co...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Conclusions:This retrospective study illustrates that there are patients for whom PSG gave a false-negative study. Patients who had negative PSG and positive HSAT are more likely to be older and have the diagnosis of hypertension. Sleep physicians may consider repeat testing with HSAT in patients with a negative PSG and clinical symptoms of OSA.Commentary:A commentary on this article appears in this issue on page 1839.Citation:Lipatov K, Hayek A, Ghamande S, Boethel C, Chen W, Jones S. Predictors of obstructive sleep apnea on home sleep apnea test after a negative attended polysomnography.J Clin Sleep Med. 2018;14(11):1889–1894.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Conclusion: Despite increases in age at the time of KT, the absolute risk of perioperative MACEs has remained stable from 2004 to 2013. HF is a major component of postoperative MACEs in KT. Malnutrition and pulmonary hypertension are major nontraditional predictors of perioperative MACE outcomes.Cardiorenal Med 2019;9:51 –60
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research
AbstractBackgroundPreterm birth increases the risk of hypertension and kidney disease. However, it is unclear when changes in blood pressure (BP) and renal function become apparent and what role obesity and sex play. We hypothesized adolescents born preterm have higher BP and worse kidney function compared to term in an obesity- and sex-dependent manner.MethodsCross-sectional analysis of 14-year-olds born preterm with very low birth weight (n = 96) compared to term (n = 43). We used generalized linear models to estimate the associations among preterm birth and BP, estimated glomerular filtration...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conditions:   Overweight and Obesity;   Diabetes;   Hypertension;   Dyslipidemias;   Cardiovascular Diseases Intervention:   Behavioral: PAI Sponsor:   Ohio University Recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: Available online 13 November 2018Source: Pregnancy HypertensionAuthor(s): Emma von Wowern, Karin Källén, Per OlofssonAbstractIntroductionIt might in the future be valuable to screen for increased maternal arterial stiffness, i.e. low compliance, since it is associated with development of hypertensive complications in pregnancy. Digital pulse wave analysis (DPA) is an easy and manageable method for arterial stiffness assessment. We aimed to investigate gestational influence on DPA variables longitudinally, and establish gestational age-adjusted reference values in normal pregnancy.MethodsDPA me...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Conclusion: After adjustment, patients with rhabdomyolysis were not at an increased risk of HTN compared to patients without rhabdomyolysis. eGFR was paradoxically higher in patients with rhabdomyolysis. There was no association found between rhabdomyolysis and mortality.Am J Nephrol 2018;48:399 –405
Source: American Journal of Nephrology - Category: Neurology Source Type: research
Study of remote communities in Venezuelan rainforest sheds fresh light on hypertensionA western lifestyle might be the reason blood pressure tends to rise with age, according to a study of remote tribal communities.Hypertension is a key risk factor for cardiovascular disease, and in many developed countries, including the UK, the likelihood of developing increases with age.More than a quarter of adults in England have high blood pressure, withrecent figures showing the proportion rises to 58% among those aged 65-74.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: High blood pressure Society Science Health & wellbeing Life and style Ageing Venezuela Americas World news Europe US news Source Type: news
Comparison of two tribes in the Venezuelan rain forest points to diet, rather than advancing age, as a cause of higher blood pressure.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Blood Pressure Salt Yanomami Indians Diet and Nutrition Heart Hypertension Source Type: news
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