Man who received nation's first 'breathing lung' transplant at UCLA thankful for gift of life

  Fernando Padilla could barely breathe or walk more than a few steps. An incurable disease, pulmonary fibrosis, was causing his lungs to turn to hardened scar tissue, and he was permanently tethered to an oxygen tank. His only hope was a double lung transplant.   In November 2012, he got an early-morning call that a pair of donor lungs was available.   Upon arriving at Ronald Reagan UCLA Medical Center, he was told of a new study testing an experimental device — a portable organ-preservation system that keeps donor lungs functioning and "breathing" in a near-physiologic state outside the body during transport to a recipient, instead of the standard method, in which the organs are kept in an icebox in a non-functioning, non-breathing state.    Padilla consented to participate in the study and was randomized to become the first patient at UCLA — and in the United States — to undergo the 'breathing lung' transplant using the TransMedics Organ Care System (OCS).   "If they've got new technology to deliver the lungs still breathing, I think that would be better than trying to wake them back up again after being on ice," said the former construction worker, who had helped build the very same hospital where he was now a patient. "I'm just following technology."   With the OCS, the lungs are removed from a donor's body and are placed in a mobile high-tech box, where they are immediately revived to a w...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Source: BMJ Comments - Category: General Medicine Source Type: forums
You and your partner just went into service when the radio begins to chirp, “Unit 10, respond Code 3 to Seniorville Nursing Facility for an 85-year-old female with altered mental status.” You kick the truck into gear and are quickly on scene. The patient’s nurse tells you that the patient has been at the facility for three days for rehabilitation after a hip replacement that occurred one week ago. The patient was initially OK, but over the last 24 hours has been anorexic (i.e., not eating), agitated and is refusing to allow healthcare providers to assess her. Her condition has become so severe that they b...
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Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disea se Interventions:   Drug: Placebo Tablet;   Drug: Ralinepag Tablet, Extended Release Sponsor:   Arena Pharmaceuticals Recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Hypertension Interventions:   Drug: amlodipine+spironolactone;   Drug: amlodipine+indapamide Sponsors:   Peking University Third Hospital;   University of Michigan;   Peking University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
NNLM MAR is pleased to share successes of health outreach projects and activities in our region. Learn what your amazing colleagues are doing to increase access to quality health information for the communities they serve. Connections4Health Connections4Health is a program from the Southwest Pennsylvania Area Health Education Center (AHEC) designed to collaborate with community health centers, public libraries and other community-focused organizations to address the broader, unmet social health needs of their patients or patrons. These unmet needs may include food security, employment, housing, or utility assistance. The ...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Member Highlights Source Type: news
Antagonistic pleiotropy is the name given to a particular view on the evolution of aging. Natural selection will favor optimization of capacity in early life, when reproduction is possible, but not the optimization of capacity in late life. Given a system in which the decline of aging is already happening to some degree, there will be further selection of processes that work well at the outset but cause harm later on in life. The adaptive immune system is an example of the type: it is highly effective in youth, due to its capacity for memory, but runs down and malfunctions in the later life context of trying to maintain me...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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AbstractSpontaneous reporting is the primary method used in pharmacovigilance (PV) to detect drug safety signal. Specific criteria used in pharmacovigilance to prove accountability of a drug are rarely present in rare disease. The low number of alerts also makes it challenging. The aim of this commentary is to raise awareness among pharmacists on issues and opportunities for pharmacovigilance in rare diseases, taking pulmonary arterial hypertension (PAH) as example, from which a subset of cases are drug-induced. It is demonstrated how a dedicated program named VIGIAPATH created to reinforce pharmacovigilance of drug-induce...
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Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: All Immunology, All Cerebrovascular disease/Stroke Case Source Type: research
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