Allogeneic bone marrow versus peripheral blood stem cell transplantation for hematological malignancies in children: a systematic review and meta-analysis

Hematopoietic cell transplantation is an essential and often the sole treatment strategy for relapsed and refractory hematological malignancies. Patients and health care professionals expect to achieve long-term survival with intensive chemotherapy, total body irradiation, and allogeneic immune reactions caused by graft versus leukemia effect [1]. Controlling treatment-related mortality is also a key to successful hematopoietic cell transplantation. Adverse events after hematopoietic cell transplantation include the immune reaction called graft versus host disease (GVHD), bacterial, viral, and fungal infections, and hepatic sinusoidal obstruction syndrome [1].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research