The Effects Of Potassium Channel Opener P1075 On Isolated Saphenous Vein Obtained From Patients With And Without Type 2 Diabetes Mellitus

Background and Aims: Previously, it has been shown that the potassium channel openers (PCOs) relax human vascular grafts by activation of smooth muscle ATP-sensitive potassium (KATP) channels. In patients with type 2 diabetes mellitus (T2DM) a cascade of complex signalling pathway caused by prolonged hyperglycemia leads to impair response of blood vessels to different vasoconstrictors or vasodilators. Thus, the objective of our study was to investigate difference between relaxant effects of PCO P1075 on the human saphenous vein (HSV) obtained from patients with and without T2DM.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Posters 26 - 29 May, 2019 Source Type: research