The Capacity Of Cerebrospinal Fluid To Promote Cholesterol Efflux Through Abca1 And Abcg1 Is Specifically Impaired In Alzheimer ’S Disease Patients

Background and Aims: HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes towards the neurons that rely on this supply for their functions. Dysregulation of cerebral cholesterol homeostasis has been associated to neurodegenerative disorders, including Alzheimer's disease (AD). We evaluated whether cholesterol efflux capacity of CSF (CSF-CEC) is impaired in AD and in non-AD related dementia.

Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: F. Zimetti, C. Marchi, M.P. Adorni, P. Caffarra, N. Ronda, M. Spallazzi, F. Barocco, D. Galimberti, F. Bernini Tags: Posters 26 - 29 May, 2019 Source Type: research