15-Lipoxygenase 1 in nasal polyps promotes CCL26/eotaxin 3 expression through extracellular signal-regulated kinase activation

15-Lipoxygenase 1 (15LO1) is expressed in airway epithelial cells in patients with type 2 –high asthma in association with eosinophilia. Chronic rhinosinusitis with nasal polyps (CRSwNP) is also associated with type 2 inflammation and eosinophilia. CCL26/eotaxin 3 has been reported to be regulated by 15LO1 in lower airway epithelial cells. However, its relation to 15LO1 in patients wit h CRSwNP or mechanisms for its activation are unclear.

Source: Journal of Allergy and Clinical Immunology - July 10, 2019 Category: Allergy & Immunology Authors: Zhipeng Li, Ming Zeng, Yanhan Deng, Jinming Zhao, Xiuxia Zhou, John B. Trudeau, Ezequiel Goldschmidt, John A. Moore, Hongwei Chu, Weitian Zhang, Shankai Yin, Zheng Liu, Y. Peter Di, Stella E. Lee, Sally E. Wenzel Source Type: research