A pilot study to determine the effects of nasal co-phenylcaine on drug-induced sleep endoscopy

ConclusionsOur pilot study supports the use of co-phenylcaine nasal spray during DISE and the positive effects of the nasal spray do not influence the grading outcome. Importantly, the decongestant enhances the nasal assessment during DISE and potentially aids in the diagnosis of nasal obstruction while the nasal anaesthetic component may be beneficial by reducing nasal discomfort during DISE and thereby helping to reduce the total dose of intravenous anaesthetic administered. However, further studies on a larger population are needed to confirm our results.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research

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BACKGROUND: Sleep-wake disturbances are underevaluated among children with acquired brain injury surviving critical care. We aimed to quantify severity, phenotypes, and risk factors for sleep-wake disturbances. METHODS: We performed a prospective c...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 20 November 2019Source: Surgery (Oxford)Author(s): Swathi P. Pinto, Glen M. PintoAbstractCardiorespiratory complications are among the most common causes of postoperative morbidity and mortality and impose a significant financial burden on the NHS. Patients with premorbid cardiorespiratory diseases can be identified preoperatively with a thorough history taking along with targeted investigations. Preoperative evaluation, risk assessment and stratification allows for clear identification of higher risk patients who would benefit from preoperative medical optimization, appropriate planning ...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
This article focuses on the perioperative care of patients, including pharmacological considerations of common medications used.
Source: Surgery (Oxford) - Category: Surgery Source Type: research
AbstractTo investigate the efficacy of exogenous administration of melatonin and melatonin receptor agonists for the improvement of delirium, sleep, and other clinical outcomes of subjects in the intensive care unit (ICU). We carefully searched three electronic databases, i.e., Pubmed/Medline, Embase, and Cochrane library, to retrieve randomized controlled trials (RCTs) administrating melatonin or melatonin receptor agonists to adult subjects admitted to the ICU. Useful data such as the prevalence of delirium, duration of sleep, number of awakenings per night, duration of mechanical ventilation, and ICU stay as well as in-...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Florencia Chena-Becerra, Genaro Alfonso Coria-Avila, Luis Beltrán-Parrazal, Jorge Manzo, María Leonor López-MerazAbstractPrevious research in female rats showed that induction of status epilepticus (SE) during infancy impairs proceptive sexual behavior at the long run in adulthood but temporarily, since full proceptivity is recovered after four mating trials. In male rats, such equivalent effects have not been explored yet. Thus, SE was experimentally induced by injecting lithium chloride (3 mEq/kg, i.p.) in thirteen-d...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Review Article Source Type: research
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Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
The number and complexity of procedures performed by gastroenterologists are increasing in the United States.1,2 In addition, the number and complexity of antithrombotic agents are growing.3 These concurrent trends may lead to confusion among providers on the  appropriate management of these drugs during endoscopy. The skilled clinician must balance the risks of thrombosis, including myocardial infarction and stroke, against the risks of procedure-related hemorrhage, which can be potentially fatal.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Biliary cannulation is the beating heart of ERCP. The vast majority of ERCP procedures involve this maneuver, and (with rare exceptions) a failure on the part of the endoscopist to achieve this milestone equates to the failure of the entire procedure.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Thanks for these comments and questions.1 Essentially all of the lesions in our study2 were removed piecemeal. The lesions in the avulsion arm of our study had a mean size of 30.6  mm. The 17.5% recurrence rate in the avulsion arm of our study is typical of many EMR series of lesions in that size range, including those from the world’s most experienced center.3 Recurrence rates after endoscopic piecemeal mucosal resection (EPMR) can be expected to fall with the introductio n of thermal treatment of the margins of EPMR defects.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
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