Palliative Care Approach to Chronic Diseases: End Stages of Heart Failure, Chronic Obstructive Pulmonary Disease, Liver Failure, and Renal Failure.

Palliative Care Approach to Chronic Diseases: End Stages of Heart Failure, Chronic Obstructive Pulmonary Disease, Liver Failure, and Renal Failure. Prim Care. 2019 Sep;46(3):415-432 Authors: Mechler K, Liantonio J Abstract Management of chronic diseases is often palliative by definition. Empowering primary care providers to manage symptoms and effectively prognosticate is necessary for this challenging population. In this article, the authors focus specifically on end-stage congestive heart failure, chronic obstructive pulmonary disease, end-stage kidney disease, and end-stage liver disease and how palliative principles can guide decision making and symptom management in these disease states. Special considerations in advance care planning, initiation and cessation of advanced therapies, and discussions on when to initiate hospice are included in this article. PMID: 31375190 [PubMed - in process]
Source: Primary Care - Category: Primary Care Authors: Tags: Prim Care Source Type: research

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This study evaluated whether CM improved psychosocial status and prevented rehospitalization in patients with HF in comparison with self-management education (SM), and usual care (UC).We randomly allocated 59 patients into 3 groups; UC (n = 19), SM (n = 20), and CM (n = 20). The UC group received one patient education session, and the SM and CM groups participated in disease management programs for 12 months. The CM group received telemonitoring concurrently. All groups were followed up for another 12 months. Data were collected at baseline and at 6, 12, 18, and 24 months.The primary endpoint was quality of life (QOL). Sec...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Authors: Taniguchi Y, Sakakura K, Yuri K, Nomura Y, Tamanaha Y, Akashi N, Tsukui T, Yamamoto K, Wada H, Momomura SI, Yamaguchi A, Fujita H Abstract Transcatheter aortic valve implantation (TAVI) has been recognized as a standard therapy for severe aortic valve stenosis. However, since some patients who receive TAVI have poor outcomes, the predictors of clinical outcomes after TAVI are important. The aim of this study was to investigate the association between appetite and long-term clinical outcomes.We screened consecutive cases who received TAVI at our medical center between July 2014 and October 2018. A total of ...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Authors: Kawashima K, Hirashiki A, Nomoto K, Kokubo M, Shimizu A, Sakurai T, Kondo I, Washimi Y, Arai H, Toba K, Murohara T Abstract The Kihon Checklist (KCL) is a reliable tool for determining frailty status in the elderly. However, there is no information in the literature about the relationship between frailty status and exercise capacity. Here, we examined the associations between cardiopulmonary exercise testing parameters and frailty status in elderly patients with stable heart failure (HF).Ninety-two elderly patients with stable HF were evaluated using cardiopulmonary exercise testing and the KCL. A KCL scor...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Authors: Fan Q, Tao R, Zhang H, Xie H, Xi R, Wang F, Xu Y, Zhang R, Yan X, Gu G Abstract Inflammatory factors have specific value in acute myocardial infarction (AMI). Our previous studies have identified the prognostic value of interleukin (IL)-34 during chronic heart failure. However, the potential impact of IL-34 on AMI remains unknown.Serum IL-34 was measured in 287 AMI patients, and they were followed up for the composite endpoint, including cardiovascular death, heart failure hospitalization, recurrent nonfatal myocardial infarction (MI), and nonfatal stroke.IL-34 levels were significantly associated with the...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Condition:   Pulmonary Disease, Chronic Obstructive Intervention:   Sponsors:   AstraZeneca;   University of Oxford Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   COPD Intervention:   Other: Home PIFR monitoring with InCheck Dial Sponsor:   Michael (Brad) Drummond, MD, MHS Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cholestatic Liver Disease Intervention:   Drug: Maralixibat Sponsor:   Mirum Pharmaceuticals, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study aimed to determinate if HgCl2 causes an AKI course with temporary activation of ERS and if this mechanism is involved in kidney cell death. Male mice were intoxicated with 5 mg/kg HgCl2 and sacrificed after 24, 48, 72, and 96 h of mercury administration. The kidneys of euthanized mice were used to assess the renal function, oxidative stress, redox environment, antioxidant enzymatic system, cell death, and reticulum stress markers (PERK, ATF-6, and IRE1α pathways). The results indicate temporary-dependent renal dysfunction, oxidative stress, and an increase of glutathione-dependent enzymes inv...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Obesity is associated with Henoch-Schönlein Purpura Nephritis and development of end-stage renal disease in children. Ren Fail. 2019 Nov;41(1):1016-1020 Authors: Zheng X, Chen Q, Chen L Abstract Objectives: To explore the association of obesity with the occurrence of Henoch-Schönlein Purpura Nephritis (HSPN) and development of end-stage renal disease (ESRD) in children with Henoch-Schönlein Purpura (HSP).Methods: This was a retrospective study of 446 pediatric patients with diagnosed HSP. All patients' demographic characteristics, clinical features, and laboratory data were collected fro...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Hepatic Encephalopathy
Source: Clinics in Liver Disease - Category: Gastroenterology Source Type: research
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