Spatial and functional heterogeneity of follicular helper T cells in autoimmunity.

Spatial and functional heterogeneity of follicular helper T cells in autoimmunity.
Curr Opin Immunol. 2019 Jul 30;61:1-9
Authors: Seth A, Craft J
Abstract
Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicular spaces - either in secondary lymphoid or non-lymphoid tissues. Both follicular and extrafollicular T helper cells drive autoantibody-mediated autoimmunity. Interfering with B cell help provided by T cells can ameliorate autoimmune disease in animal models and human patients. The next frontier in Tfh cell biology will be identification of Tfh cell-specific pathogenic changes in autoimmunity and exploiting them for therapeutic purposes.
PMID: 31374450 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - July 29, 2019 Category: Allergy & Immunology Authors: Seth A, Craft J Tags: Curr Opin Immunol Source Type: research