Misuse of serological screening tests for celiac disease in children: A prospective study in Italy

Despite a well-established diagnostic algorithm for celiac disease, it remains unclear whether prescriptions for celiac serological tests comply with the current pediatric guidelines.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Alimentary Tract Source Type: research

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Celiac disease diagnostics begin by measuring autoantibodies, which may fail to identify seronegative patients. Duodenal lesion in the absence of antibodies is scarcely studied, especially in children.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Alimentary Tract Source Type: research
Publication date: Available online 26 December 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Kevin Jurgensmeier, Lee J. Hixson, David C. PfeifferSummarySymptomatic coagulopathies in celiac disease (CD) are rare. Here, we report a profound case of coagulopathy in a celiac. A 66-year old female without liver disease or anti-coagulation therapy presented with multiple ecchymoses, guaiac positive melanic stool, and a recent 4.5 kg weight loss. Laboratory values included hemoglobin, 3.8 g/dL; MCV, 66 fL; serum iron, 17 μg/dL; platelet count, 580 K/μL; white count, 14.2&n...
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Coeliac disease is a chronic and systemic autoimmune condition triggered by gluten ingestion in genetically predisposed subjects. Currently, the only effective treatment available is a strict, lifelong gluten-free diet. However, patients perceive gluten withdrawal as an unsustainable burden in their life and some of them can exhibit persistent symptoms despite a strict diet. Thus, gluten-free diet represents a challenge, leading scientists to look for alternative or complementary treatments. This review will focus on non-dietary therapies for coeliac disease highlighting six therapeutic strategies: (1) decreasing gluten im...
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
ConclusionCD is common in PHT of different etiology especially in cCLD, NCPH and Autoimmune hepatitis (AIH), however etiological basis for this association is still to be defined. The likelihood of CD is higher in liver disease as compared to general population and these patients should be screened for CD.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
Gluten? Lactose? Stomach pain? Digestive troubles? Way too many people suffer from gastrointestinal issues, and much less are aware of the digital technologies that can come to their aid. Did you know that digestibles could successfully replace the dreaded colonoscopy? Or have you heard about microbiome testing? What about the swarm of health apps supporting dietary restrictions? We took a deep breath and jumped into the universe of digital technologies just to bring you as much information about the future of gastroenterology as possible. Will you jump after us? IBS, colorectal cancer, and other animals Referring to...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Genomics Health Sensors & Trackers diet dieting digestibles digestion digital health gastro gastroenterologist gastroenterology gastrointestinal gluten gut Innovation lactose microbiome stomach techno Source Type: blogs
The authors deeply apologize for an error that appeared in the article by Nurmi et al. in the issue of January 2018 of the Digestive and Liver Disease (Dig Liver Dis. 2018;50:27 –31), entitled ‘Celiac disease or positive tissue transglutaminase antibodies in patients undergoing renal biopsies’. The error concerns the formula of eGFR (estimated glomerular filtration rate), which was formed erroneously. However, the correct values of creatinine and age were used. The wr ong formula neither changes the end results nor the message of the study.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Corrigendum Source Type: research
AbstractDefective spleen function increases susceptibility to bacterial infections which can be prevented by vaccine prophylaxis. Splenic hypofunction can be found in a number of autoimmune disorders; however, no data are available regarding autoimmune atrophic gastritis (AAG), autoimmune enteropathy (AIE) and autoimmune liver disease (AILD). Peripheral blood samples from patients with AAG (n = 40), AIE (n = 3) and AILD (n = 40) were collected. Patients affected by autoimmune disorders already known to be associated with splenic hypofunction, i.e. coeliac disease (CD) and ulcerativ...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
After more than 15 years since its introduction into clinical practice, indications for device-assisted enteroscopy have greatly expanded. Alongside the consolidated indications such as the diagnosis and treatment of small bowel bleeding, Crohn ’s disease, hereditary polyposis, small-bowel tumors and complicated celiac disease, device-assisted enteroscopy is nowadays largely used to perform endoscopic retrograde cholangiopancreatography in patients with altered anatomy, stent placement, retrieval of foreign bodies, direct insertion of je junal feeding tubes, and in selected cases of incomplete colonoscopy.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
In this study, the gut microbiota of 30 LC patients and 30 healthy controls were examined via next-generation sequencing of 16S rRNA and analyzed for diversity and biomarkers. We found that there was no decrease in significant microbial diversity (alpha diversity) in LC patients compared to controls (P observed = 0.1422), while the composition (beta diversity) differed significantly between patients and controls (phylum [stress = 0.153], class [stress = 0.16], order [stress = 0.146], family [stress = 0.153]). Controls had a higher abundance of the bacterial phylum Actinobacteria and genus Bifidobacterium, while patients wi...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusions: Liver involvement in celiac children is now less frequent than previously reported, possibly due to changing CD epidemiology. Younger age is the only risk factor. Associated autoimmune liver disease is rare.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Article: Gastroenterology: Celiac Disease Source Type: research
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