Omeprazole-Induced Dysbiosis Impacts Bile Acid Metabolism In Mice And Humans

Background and Aims: Proton pump inhibitors (PPIs) such as omeprazole are gastric acid-suppressing agents that are used to treat gastroesophageal reflux disease and peptic ulcers. In contrast, PPIs are also associated with gut microbiota dysbiosis and increased cardiovascular disease risk. However, proof of a causal link between PPI use, dysbiosis and cardiovascular disease is missing.

Source: Atherosclerosis - August 2, 2019 Category: Cardiology Authors: A.G. Lopez Manosalva, T. Yntema, L. Chen, S. Garmaeva, S. Hu, M. Koster, M. Koehorst, M.H. Hofker, A. Vich, F. Kuipers, J. Fu, D. Koonen Tags: E-poster session Source Type: research