Effectiveness and safety of long-term benzodiazepine use in anxiety disorders: a systematic review and meta-analysis

Long-term benzodiazepines (BZDs) use is not endorsed in the treatment guidelines for anxiety disorders, but is prevalent in the real-world clinical settings. A systematic literature review was performed by using PubMed (last search: May 2019) to identify randomized controlled trials (RCTs) or maintenance studies following RCT that examined the effectiveness of BZDs in patients with anxiety disorders for a duration of 13 weeks or more. Meta-analyses were then conducted regarding changes in the Hamilton Anxiety Rating Scale (HAM-A) scores from baseline through endpoint, all-cause discontinuation, side effects, and the numbers of panic attacks at endpoint. Eight studies were identified (N = 1228). There were no significant differences in all outcomes between BZDs and antidepressants after the initial 8-week treatment. While no significant difference was noted in the HAM-A score changes between BZDs and placebo, BZDs resulted in a lower discontinuation rate and more frequent constipation and dry mouth than placebo. Our study indicates that for those who respond to an initial 8-week treatment, continuing BZDs is equivalent to antidepressants in efficacy and safety. However, the limited number of studies warranted further investigations of the long-term effectiveness and safety of BZDs.
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Review Source Type: research

Related Links:

ConclusionsFurther longitudinal research is needed to clarify the association between paternal mental health disorders other than depression, and adolescent anxiety or depression. Mechanisms in this relationship should also be further explored, and could be informed by existing models on younger children.
Source: Journal of Adolescence - Category: Child Development Source Type: research
Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
Anxiety is rippling across the globe as Beijing attempts to contain the growing outbreak.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Publication date: Available online 25 January 2020Source: Journal of Functional FoodsAuthor(s): Nidyedja Goyanna Gomes Gonçalves, José Ismael Feitosa de Araújo, Francisco Ernani Alves Magalhães, Francisco Rogênio Silva Mendes, Marina Duarte Pinto Lobo, Ana Cristina de Oliveira Monteiro Moreira, Renato de Azevedo MoreiraAbstractBreadfruit (Artocarpus altilis) is a staple food in tropical regions and has several uses. The aim of this study was to establish the nutraceutical potential of an enriched protein fraction of breadfruit pulp (PFBp). PFBp was characterized by Fourier transform infrar...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 7 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jennifer A. Dantzer, Corinne A. Keet
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
There is an epidemic in brain diseases, which have quadrupled in the last 21 years. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia subscribers-only Source Type: blogs
You're reading 5 Surprising Things Stress Can Do to Your Body, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. You just got off a terrible meeting, your boss gave you an impossible deadline for the next project, your team is pushing you to make extra hours, and you still need to pick up the kids at school. Your body is in a “fight or flight response.” Your stress levels are high, you feel your breath get quicker and even feel your heart beating faster than usual. Although this is all a natural response from y...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement stress Source Type: blogs
​BY ARJUN BHARADWAJ; CHRISTOPHER RUSSELL; MARGARET GAVOR, MBCHB, MPH; &KHALID MALIK, MDA 63-year-old man presented with hand tremors, dizziness, and expressive aphasia. His symptoms had started a month earlier, and this was his third visit to the ED for these symptoms, though the aphasia was a new symptom. He said his symptoms had been growing worse.The patient's symptoms had been previously attributed to alcohol intoxication. He also said he had been experiencing vomiting, dry heaving, bilateral tinnitus, and dizziness but no fever, chills, chest pain, abdominal pain, shortness of breath, vision and hearing problems...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Susan Schneider Williams, Robin Williams’ widow, wrote a devastating account of her husband’s final year of life before he died by suicide in 2014. An autopsy revealed that Robin Williams had Lewy body disease, an umbrella term used to describe both Parkinson’s disease dementia and dementia with Lewy bodies. In a letter this week addressed to neurologists, Susan described the “terrorist” who lived inside her husband’s brain and caused him to forget his movie lines, plagued him with delusions and paranoia, and engulfed him in fear, anxiety and depression. Her account of his medi...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
This article originally appeared on YourTango. More from YourTango: 10 Things Your Friend With Anxiety Wants You To Know 11 Things Anxious People Are Tired Of Being Anxious About The 35 Small Things You Can Do Right Now To Feel Awesome Perk Up! 13 Reasons To Love Your Small Boobs How To Have Better Sex Than You Can Even Imagine Also on HuffPost: -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
More News: Anxiety | Constipation | Panic Disorder | Psychiatry | Study