Chronic ketamine abuse is associated with orexin-A reduction and ACTH elevation

ConclusionsThis study showed that KD patients had persistent orexin-A reduction and stress hormone dysregulation in early abstinence. The anxious phenotype of KD might be associated with a lower orexin-A expression. These results point to a promising pathway to investigate the neurochemical mechanisms of ketamine addiction.
Source: Psychopharmacology - Category: Psychiatry Source Type: research