Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors
Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies. Here, we evaluated for differential gene expression (DGE) in peripheral blood between breast cancer survivors with and without PIPN and for neuroinflammatory (NI) related signaling pathways and whole-transcriptome profiles from other experiments. Pathway impact analysis identified 8 perturbed NI related pathways.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Christine Miaskowski, Kimberly Topp, Yvette P. Conley, Steven M. Paul, Michelle Melisko, Mark Schumacher, Margaret Chesney, Gary Abrams, Jon D. Levine, Kord M. Kober Source Type: research
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