From epithelial remodelling to carcinogenesis

Publication date: Available online 2 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Leszek Satora, Jennifer Mytych, Anna Bilska-Kos, Katarzyna KoziołAbstractThe novel cancer theory named ‘The tissue organization field theory’ (TOFT) suggests that carcinogenesis is a process analogous to embryonic development, whereby organs are formed through interactions among different cell types. The suggested ‘morphological remodelling’ of the epithelium under hypoxia in gut breathing fish (GBF) has many common features with carcinogenesis. It appears that research into the relationship among epidermal growth factor receptor (EGFR), hypoxia inducible factor (HIF) as well as hypoxia and normoxia states in GBF fishes can be crucial in learning about the steering mechanisms of squamous epithelium proliferation, leading to a better understanding of carcinogenesis.
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research