Use of the TP5 Peptide for the Treatment of Cancer

GBM is the most aggressive form of brain cancer. The current standard of care against GBM is a combination of surgery, chemotherapy and radiotherapy. However, after standard treatment, the cancer usually recurs – emphasizing a need for new targets and better alternatives. A promising target is cyclin-dependent kinase 5 (CDK5), the hyperactivity of which has been shown to have a role in cancer progression. TP5/TFP5, a small peptide inhibitor against CDK5, was developed at the National Institutes of Health and modified to increase its passage through the blood brain barrier. Researchers at the NCI and NINDS demonstrated that TP5 decreases cell viability and increases programmed cell death in GBM and CRC cell lines with aberrant CDK5 activity. TP5 was found to impair DNA repair by inhibiting CDK5 and acted additively and synergistically with DNA-damaging agents (e.g. temozolomide, irinotecan, irradiation) used in treatment of GBM and colon carcinoma. TP5 decreased the tumor volume and increased the overall survival of orthotopic glioblastoma mouse models.TheNeuro-Oncology Branch is seeking statements of capability or interest from parties interested in licensing this invention to further develop, evaluate, or commercialize TP5 for novel treatment of GBM and/or other cancers with aberrant CDK5 expression.IC: NCINIH Ref. No.: E-007-2019Advantages: TP5:Decreases the tumor volume and the proliferation rate of GBM in mouse modelsCan cross the blood-brain barrier, ov...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research