Diagnostic performance of 18F ‐fluorodeoxyglucose positron emission tomography in the evaluation of glioma

ConclusionThe combination of FDG ‐PET/CT and gadolinium‐enhanced MRI demonstrated marked improvement in identifying potential high‐grade disease over each modality alone. Increased FDG uptake without gadolinium enhancement rarely occurred and identified high‐grade histology in a small number of patients. Due to limited sens itivity and NPV, a negative FDG‐PET/CT alone, or in combination with MRI, should not guide a decision for observation where surgery would otherwise be recommended.
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Medical Imaging —Radiation Oncology—Original Article Source Type: research

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Abstract13N-Ammonia (13N-NH3) is widely used positron emission tomography/computed tomography (PET/CT) radiotracer for the measurement of myocardial blood perfusion; the possible role of13N-NH3 PET or PET/CT in oncological disease is not yet clear. Aim of this review is to evaluate the diagnostic performances of13N-NH3 PET in this field. A comprehensive computer literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted including articles up to June 2019. Eighteen articles were finally included in the review. From the analyses of the selected studies, the following main findings could be drawn: (1)...
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
In Reply We thank Dr Pross for his reply to our article. The first point raised considers imaging in children with congenital unilateral sensorineural hearing loss (USNHL) without neurological symptoms to rule out retrocochlear malignant abnormalities. We addressed this issue in the discussion section of our review. One glioma was found on magnetic resonance imaging (MRI) but missed on computed tomographic (CT) scan results, in a total of 1504 included patients. A precise estimate of risk of malignant abnormality is unfortunately not possible, owing to lack of systematic inclusion of patients with congenital USNHL without ...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
ConclusionsMicroscope-based AR can be reliably applied to intradural spinal tumor surgery. Automatic AR registration ensures high precision and provides an intuitive visualization of the extent of the tumor and surrounding structures. Given this setting, all advanced multi-modality options of cranial AR can also be applied to spinal surgery.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Conclusion We ascribe the incorrect diagnosis to insufficient understanding on imaging manifestations of brain neoplasm as well as clinical features of parasitosis. Thus, we review the MRI, FDG-PET-CT, MRS and DTI data of this case according to the timeline, refer to relevant studies, and point out the pitfalls. With a long course of slowly progressing, this was a rare case of secondary glioblastoma with the absence of isocitrate dehydrogenase 1 (IDH1) gene mutation.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 14 August 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Kara L. Krajewski, Silvia Hernández-Durán, Jakob Matschke, Tammam AbboudAbstractWe demonstrate two unusual cases of malignant swelling and rapid fatal outcome as a form of the “wounded glioma syndrome” after biopsy of diffuse anaplastic gliomas in two young men.In the first case, the lesion was throughout the right temporal, parietal and occipital lobes and extending into the basal ganglia with a small contrast-enhancing lesion in the temporal lobe. The patient underwent an open biopsy of the contrast...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analys...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
This article discusses the main advantages and disadvantages of combined PET/MRI compared to other conventional or more widely available imaging tools, such as MRI or combined positron emission tomography-computed tomography. The main uses of PET/MRI and the most commonly used PET radiotracers in providing diagnostic, prognostic and predictive information in patients with glioma are covered. PMID: 31283392 [PubMed - in process]
Source: British Journal of Hospital Medicine - Category: Internal Medicine Authors: Tags: Br J Hosp Med (Lond) Source Type: research
ConclusionThis case joins less than 20 other reported cases of oligodendroglioma bone marrow metastasis, and is one of only a handful of cases of diffuse bone metastases beyond the axial skeleton. To the best of our knowledge, the early relapse of 1p/19q codeleted anaplastic oligodendroglioma with this distribution of metastases has never been described in the literature.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Background: In the past decade, positron emission tomography/computed tomography (PET/CT) has become an important imaging tool for clinical assessment of tumor patients. Our meta-analysis aimed to compare the predictive value of PET/CT parameters regard to overall survival (OS) and progression-free survival (PFS) outcomes in glioma.Methods: Relevant articles were systematically searched in PMC, PubMed, EMBASE and WEB of science. Studies involving the prognostic roles of PET/CT parameters with OS and PFS in glioma patients were evaluated. The impact of metabolic tumor volume (MTV), maximal standard uptake value (SUVmax), an...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Conclusions: Anti-LGI1 encephalitis is a subtype of autoimmune encephalitis that results from antibodies targeted at leucine rich glioma inactivated 1 (LGI1) protein. This autoantigen is secreted from neuronal proteins and acts as a ligand for ADAM22 and ADAM23 which are epilepsy-related proteins (1). Early intervention improves long term outcomes (2). Patients may show cognitive abnormality and seizures (3). MRI results usually reveal medial temporal hyperintensity (4). Less is known regarding the F18 FDG PET evaluation of the patients. Herein, we present the results of 47 brain clusters based on FDG PET scans compared to...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
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