Functional lipid polymeric nanoparticles for oral drug delivery: Rapid mucus penetration and improved cell entry and cellular transport

This study identified the key factors involved in oral bioavailability enhancement.Graphical AbstractThe hydrophilic copolymer pHPMA associated with vitamin B12-modified chitosan-covered lipid polymeric nanoparticles (H/VC-LPNs) releases the pHPMA during mucus penetration. Endocytosis then occurs via the VB12 receptor along with caveolae and the caveolate-mediated route. The nanoparticles promote transepithelial absorption via paracellular transport and open tight junctions between intestinal cells. They also enter M-cells in Peyer's patches, thereby creating an alternate absorption route for drug delivery. Rapid mucus permeation, enhanced cellular uptake, and transepithelial absorption improved the oral absorption and bioavailability of curcumin.
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research