A review on Targeting Nanoparticles for Breast Cancer.

A review on Targeting Nanoparticles for Breast Cancer. Curr Pharm Biotechnol. 2019 Jul 31;: Authors: Alqaraghuli HGJ, Kashanian S, Rafipour R Abstract Chemotherapeutic agents have been used extensively in breast cancer remedy. However, most anticancer drugs cannot differentiate between cancer cells and normal cells, leading to toxic side effects. Also, the resulted drug resistance during chemotherapy reduces treatment efficacy. The development of targeted drug delivery offers the great promise in breast cancer treatment both in clinical applications and in pharmaceutical research as well. This review discusses recent works in the targeting methods for breast cancer cells. In this review, we concentrate on chemical methods of targeting through the use of chemical ligands. Recently, many studies have been conducted to investigate the targeting effectiveness of some molecules, such as antibodies, peptides, aptamers, vitamins, hormones, and carbohydrates. Conjugation of nanocarriers with targeting ligands is an effective therapeutic strategy to treat cancer diseases. In this review, we will discuss the targeting strategies and recently published studies (from 2015 to present) utilized for targeted drug delivery against breast cancer cells. PMID: 31364513 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research