Genome-wide analysis of androgen receptor binding and transcriptomic analysis in mesenchymal subsets during prostate development [RESOURCE ARTICLE]

We examined AR function at single-cell resolution using single-cell RNA sequencing (scRNA-seq) in male and female mesenchyme. Surprisingly, both AR and target genes were distributed throughout cell subsets, with few positive cells within each subset. AR binding was weakly correlated with target gene expression.

Source: DMM Disease Models and Mechanisms - July 24, 2019 Category: Biomedical Science Authors: Nash, C., Boufaied, N., Badescu, D., Wang, Y. C., Paliouras, M., Trifiro, M., Ragoussis, I., Thomson, A. A. Tags: RESOURCE ARTICLE Source Type: research