Current treatment of pediatric bladder and prostate rhabdomyosarcoma (bladder preserving vs. radical cystectomy)

Purpose of review To discuss alternative strategies for multimodal treatments of nonmetastatic bladder–prostate rhabdomyosarcoma performed with the aim of preserving organ function. Recent findings Bladder–prostate rhabdomyosarcomas are seldom fully resectable at presentation or after induction chemotherapy, and extensive resection might not improve survival. When an organ-sparing approach is pursued, radiotherapy might be unavoidable to achieve reliable local control of the disease. Benefits of preoperative vs. postoperative radiotherapy have yet to be investigated. Multimodal treatments may often result in bladder function impairment and erectile dysfunction. To reduce long-term side effects of radiotherapy, irradiation modalities allowing for more targeted treatment should be favoured. For this purpose, external beam proton therapy or nonradical surgery associated with brachytherapy may be viable options. Nevertheless, experience with these treatments is still limited. Advancements in lower urinary tract reconstruction make preservation of volitional voiding and erectile function possible after cystoprostatectomy. But in the context of multimodal treatment, cystoprostatectomy is reserved to patients who respond poorly to other treatments. Summary For the vast majority of bladder–prostate rhabdomyosarcoma, we believe that reliable local control of disease can only be achieved with the use of radiotherapy. Efforts should be made to find the best mod...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: PAEDIATRIC URO-ONCOLOGY: Edited by Manuela P. Hiess Source Type: research

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Publication date: Available online 19 August 2019Source: The American Journal of SurgeryAuthor(s): Katherine Bingmer, Asya Ofshteyn, David Dietz, Sharon L. Stein, Emily SteinhagenAbstractBackgroundImmunosuppressed patients have an increased risk of developing anal cancer, but little data exists regarding outcomes of this population.MethodsA retrospective review of anal cancer patients at a single academic institution from 2006-2017 was performed.Results19 (14%) of 136 anal cancer patients were immunosuppressed. Immunosuppressed patients were more likely to be hypoalbuminemic (21% vs. 6%, p=0.025), less likely to complete c...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsAbdominal wall defects from resection of cancerous masses of the abdominal wall can be closed with a contralateral rectus abdominis muscle transplant in the absence of mesh.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionsOur data suggested that miR-1307 may be involved in the resistance of ovarian cancer to chemotherapy drugs via regulation of CIC, and should be further explored as a potential therapeutic target.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
We report an unusual case of a leiomyosarcoma arising six months post myomectomy in a 16-year old female.Graphical abstractRadiographic images (A) starting with the CT of mass on day 0 followed by the CT abdomen/pelvis of second pelvic mass leiomyosarcoma on day 185, the MRI prior to staging surgery on day 317, and finishing up with the MRI of the recurrence of malignancy. Timeline of patient events (B). Our patient initially underwent a diagnostic laparoscopy with pelvic mass biopsies showing leiomyoma which was followed by an abdominal myomectomy. She re-presented to the hospital on Day 190 and urgently underwent an expl...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Priyanka A Patel, Asha S Anand, Sonia K Parikh, Akash D Patel, Rahul S KulkarniJournal of Pediatric Neurosciences 2019 14(2):86-89Burkitt lymphoma is a high-grade B-cell lymphoma with aggressive course of disease and primarily systemic nodal involvement. Primary Burkitt lymphoma with isolated central nervous system (CNS) involvement and that too in pediatric population has been rarely reported. Here, we present a case of a primary Burkitt lymphoma involving brain in an human immunodeficiency virus–positive pediatric patient who was on antiretroviral therapy. Currently, there are no established protocols or guidelines...
Source: Journal of Pediatric Neurosciences - Category: Neuroscience Authors: Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractPurposeTo report outcomes of salvage re-irradiation (re-RT) in recurrent/progressive medulloblastoma (MB).MethodsMedical records of patients treated with curative-intent re-RT as multi-modality management for recurrent/progressive MB between 2008 and 2018 were analyzed retrospectively.ResultsA total of 28 patients (median age 18  years at index diagnosis) were included. Molecular subgrouping was done using real-time reverse transcriptase polymerase chain reaction (RT-PCR) based on the differential expression of select set of 12 protein coding genes and 9 microRNAs. Fifteen of 17 (88%) patients with sonic hedge...
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsOur results suggest a role of decreased MPC1 copy number segments in reducing overall survival in glioblastoma. MPC1 deletion is associated with poor response to TMZ chemotherapy in GBM.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Cold plasma is an unusual gaseous substance in which only the electrons are heated to thousands of degrees, with the rest of the material remaining at room temperature. Purdue University researchers have advanced this field and have helped to make it...
Source: Medgadget - Category: Medical Devices Authors: Tags: Oncology Surgery Source Type: blogs
Condition:   Bladder Cancer Intervention:   Drug: Paclitaxel-binding albumin Sponsor:   Third Military Medical University Recruiting
Source: - Category: Research Source Type: clinical trials
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