Can a combination immune therapy reduce genital herpes outbreaks?

Yale investigators have shown that the combination of a vaccine and a medicated cream is a promising strategy to reduce the recurrence of genital herpes.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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In this study we have evaluated whether our OMVs vaccine is capable of overcoming the deficiencies of commercial vaccines in both controlling infections caused by PRN(-) isolate/strain and inducing memory immunity. We found that our OMVs-based formulation has a higher protective capacity against the PRN(-) bacteria than that induced with a commercial aP vaccine. We found that CD4 T cells with a tissue-resident memory (TRM) cell phenotype (CD44+CD62LlowCD69+ and/or CD103+) accumulated in the lungs of mice after the second OMVs vaccine immunization. CD4 TRM cells were also detected in mice immunized with wP vaccine, but not ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: These finding suggest that Poly-ICLC could be safely used for inducing transient innate immune responses in treated HIV+ subjects indicating promise as an adjuvant for HIV therapeutic vaccines. Trial Registration: www.ClinicalTrials.gov, identifier: NCT02071095. Introduction Innate immune dysregulation during HIV infection hinders the formation of anti-HIV adaptive immunity (1–6) resulting in rampant viral dissemination and progression to AIDS. Adherence to combination anti-retroviral therapy (cART) regimens controls viremia, restores CD4+T cell counts and reverses immune dysfunction to a larg ext...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The Editor of this journal has published this Expression of Concern to alert readers that, following publication of the article [1], it came to light that there were undeclared competing interests that have a ...
Source: Clinical and Translational Medicine - Category: Internal Medicine Authors: Tags: Correction Source Type: research
A new federal report reveals some good news about herpes: fewer Americans are getting the virus. However, nearly half of American adults have the first type of herpes simplex virus. According to the new findings, released Wednesday by the National Center of Health Statistics (NCHS)—part of the Centers for Disease Control and Prevention (CDC)—the prevalence of both strains of herpes is down. Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) can both cause outbreaks of sores. HSV-1 typically causes cold sores on or around the mouth and is often spread by kissing, and HSV-2 can cause genital outbreaks and is ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized CDC genital herpes healthytime herpes hsv 1 herpes hsv 2 herpes outbreak herpes rates herpes simplex herpes sore NCHS oral herpes percentage of people with herpes public health safe sex sexually transmitted dise Source Type: news
View Original Article Here: How Long Does Shingles Last In The Elderly? Shingles is a viral infection that follows a varicella-zoster infection, although it can take decades for symptoms of the secondary disease to emerge. The condition presents as a painful and blistering rash, but it is not life-threatening. According to the Center for Disease Control, there are nearly one million cases in the United States each year, and almost half of those cases are in older adults over age 60. Some people only see one instance of the illness, while others have recurring symptoms, but 30 percent of Americans will develop shingles at s...
Source: Shield My Senior - Category: Geriatrics Authors: Tags: Senior Safety Source Type: blogs
Herpes simplex virus causes recurrent outbreaks of painful genital or oral lesions and in some circumstances can be lethal. But treatment is currently limited to antivirals, which are only 50% effective at reducing transmission. New treatments are desperately needed — here are four of the most promising pipeline strategies.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Yeast infections don't have a monopoly on itching, burning, and weird discharge. For SELF, by Zahra Barnes. Lizzie Roberts / Getty Images In today's roundup of extremely obvious statements: The sky is blue, grass is green, and no one wants to get a yeast infection. But unfortunately, for some people with vaginas, they're a fact of life. These annoying infections happen due to an overgrowth of the naturally occurring fungus Candida albicans, and they're pretty common, affecting three out of every four women in their lifetimes, according to Mayo Clinic. Since yeast infections aren't exactly rare, when you experience th...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
I was 21 years-old when I contracted genital herpes from my boyfriend. And let me just say that I really do hate that word- herpes. It doesn't have an abbreviation, it doesn't roll off your tongue like say, chlamydia. It just kind of sticks in your mouth like a wad of stale chewing gum. So yes, I was 21. I had been having sex for about three years. And that is always what kills me when I think about the numbers. In the 18 years I have been having sex, only 3 of them have been free of this stain, this shame backpack that I have been carrying around with me for far too long. Because that's really what a life with genital h...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
The world's first injection for genital herpes could become even more powerful if used in combination with existing medicines, scientists from Indiana University believe.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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