Clustering of immune-mediated diseases in sarcoidosis

Purpose of review Sarcoidosis is an immune-mediated disease of unknown cause. Immune-mediated diseases appear to cluster in patients and in families. We review what is known on this topic for sarcoidosis, and what factors may underlie disease clustering. Recent findings In populations of patients with sarcoidosis, relative risk estimates of Sjögren's syndrome, systemic lupus erythematosus, autoimmune hepatitis, ankylosing spondylitis, multiple sclerosis (MS), celiac disease, autoimmune thyroid disease, and ulcerative colitis, varied between 2.1 and 11.6. In relatives of patients with sarcoidosis, relative risk estimates varied between 1.3 and 5.8 for sarcoidosis, MS, celiac disease, type 1 diabetes, Graves’ disease, rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Shared risk loci in key immunological pathways provide evidence for a contribution to development of multiple diseases. Identical changes in the immune status, epigenetic alterations, and environmental triggers have been detected in several diseases, and drug-induced disease is likely responsible for a small portion of co-occurring disease. Summary Clustering of sarcoidosis and other immune-mediated diseases in patients and in their relatives occurs for sarcoidosis, MS, celiac disease, Graves’ disease, and ulcerative colitis. Further research is needed to substantiate causal links and risk estimates in patients and their relatives.
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Jan C. Grutters and Marc A. Judson Source Type: research

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AbstractPurposeTo evaluate the effects of epiretinal membrane (ERM) formation on the anatomic and functional results of subjects with diabetic macular edema (DME) who are receiving intravitreal aflibercept injections (IAIs).Materials and methodsThis retrospective comparative study includes 29 eyes with DME (Group 1) and 43 eyes with DME and ERM (Group 2). After three consecutive monthly 2.0  mg IAIs, subjects received monthly follow-ups and retreatment was performed if needed. Corrected visual acuity (CVA), central macular thickness (CMT), and central macular volume (CMV) parameters were recorded tri-monthly, and the ...
Source: International Ophthalmology - Category: Opthalmology Source Type: research
Publication date: Available online 19 September 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Salvatore Di Paolo, Marco Fiorentino, Luca De Nicola, Gianpaolo Reboldi, Loreto Gesualdo, Federica Barutta, Andrea Natali, Giuseppe Penno, Paola Fioretto, Giuseppe Pugliese, Italian Society of Nephrology and the Italian Diabetes Society
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
We present a case of BP in a 33-year-old man with history of bladder exstrophy from birth and renal transplantation from 5 years ago. There was no finding in favour of his disease was caused by graft rejection, drug usage, or viral infection. Therefore, BP could be an accidental finding in this patient with idiopathic aetiology. PMID: 32943598 [PubMed - in process]
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
Authors: Ossareh S, Bagheri M, Abbasi M, Abolfathi S, Bohlooli A Abstract INTRODUCTION: Seven months after the emergence of SARS-COV-2 virus, there is paucity of data regarding the epidemiology of the virus in hemodialysis patients. We aim to present the results of the screening program implied after outbreak of COVID-19 in a referral hemodialysis ward. METHODS: We started clinical screening and obligatory mask wearing for dialysis patients and personnel on 20-Feb-2020. However 11 symptomatic COVID-19 patients emerged till day +36. On days +39 and +40 a screening program was implied including measurement of SAR...
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
CONCLUSION: In the current study, the patient's albuminuria, type of treatment and HbA1c had no effect on the RI. The study also found that an increase in the RI index could be a significant predictor of renal dysfunction and increased creatinine. PMID: 32943590 [PubMed - in process]
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 20 September 2020Source: Journal of Biomedical InformaticsAuthor(s): Meghan Reading Turchioe, Marissa Burgermaster, Elliot G. Mitchell, Pooja M. Desai, Lena Mamykina
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
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Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
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Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Khaltaev N, Solimene U, Vitale F, Zanasi A Abstract Chronic respiratory diseases (CRD) belong to major noncommunicable diseases (NCD) targeted by World Health Organization (WHO) NCD Action Plan and United Nations (UN) Sustainable Development Goal (STG) 3.4 to achieve 30% decline of mortality by the year 2030. Strong evidence is now available in the literature for therapeutic aquatic exercise interventions in improving health status of chronic obstructive pulmonary diseases (COPD) patients. However, gym-based exercises can be difficult for patients with COPD who are mainly elderly and often have co-morbidit...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
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