Peripherally derived macrophages as major phagocytes in MOG encephalomyelitis

An inflammatory demyelinating disease of the CNS with antibody against myelin oligodendrocyte glycoprotein (MOG-IgG) is now accepted as a discrete disease category of MOG encephalomyelitis (MOG-EM).1 Previous case studies described abundant accumulation of phagocytic cells (either Iba1+ and/or CD68+) at the active demyelinating lesions of MOG-EM.2–5 However, both Iba1 and CD68 can be expressed in either the microglia or macrophage.6 Recently, transmembrane protein 119 (TMEM119) has been proposed to be a reliable microglial marker that discriminates resident microglia from blood-derived macrophages in the inflamed human brain.6

Source: Neurology Neuroimmunology and Neuroinflammation - July 31, 2019 Category: Neurology Authors: Kwon, Y. N., Waters, P. J., Kim, M., Choi, Y. S., Kim, J. W., Sung, J.-J., Park, S.-H., Kim, S.-M. Tags: All Immunology, Autoimmune diseases, All Clinical Neurology, All Demyelinating disease (CNS), Acute disseminated encephalomyelitis Clinical/Scientific Notes Source Type: research