Medical Device Manufacturing Trends: Finding Simplicity Amid Complexity

Manufacturing trends for medical applications using pressure-sensitive adhesives (PSAs) can be as diverse as the products the PSAs hold together, whether wearables, wound care solutions, diagnostic instruments, or ostomy devices. Yet there is some common ground. One of the overarching trends can be summed up as follows: The simpler the supply chain, the better. Device manufacturers and their supply chain partners are always looking for ways to leverage manufacturing strategies that are stable, scalable and efficient. Yet at the same time, device performance requirements can be quite complex. It may seem paradoxical, but sometimes simplifying the supply chain is the key to making even the most sophisticated devices more economically. Manufacturing: Simplicity and Efficiency As every device manufacturer knows, insurer reimbursement only goes one way — lower. Thus, there is a continual pressure to make products more efficiently. Device makers’ bottom lines benefit when they can achieve equivalent results with a simplified materials roster or even slightly different device designs. Here is where a materials supplier may be able to help an original equipment manufacturer (OEM) to see a product in a fresh light. For example, a wearable device might have a complex sandwich-like construction of many layers. An advanced materials supplier, particularly one with in-house R&D capabilities and custom formulation services, might be able to suggest a con...
Source: MDDI - Category: Medical Devices Authors: Tags: Contract Manufacturing Source Type: news

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Conclusion: The current study demonstrated no analgesic effects of postoperative chlorzoxazone administration compared with placebo on acute or chronic postoperative pain 12 months following TKR and THR.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: Most clinicians agreed that OIH is a complication of opioid therapy, but were divided regarding the prevalence of OIH, etiological factors, and optimal management.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
We examined variables that influence the provision of analgesia in a pediatric emergency department that uses TNIA. Methods: A 4-year retrospective cohort study of all children with triage pain scores ≥1 was conducted. Data on demographics and patients’ and nurses’ characteristics were collected. Logistic regression analyses were used to examine the effect of multiple variables on the provision of any analgesia and opioid analgesia. Results: Overall, 28,746 children had triage pain scores ≥1; 14,443 (50.2%) patients received analgesia of any type and 1888 (6.6%) received opioid analgesia. Mean time ...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: The study provides important new findings regarding the associations between social factors and physical and psychological functioning of individuals with chronic pain, supporting biopsychosocial models.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: Our findings support the notion of a positive association between inflammatory biomarkers and nonspecific LBP, specifically for CRP, TNFs, and IL-6. Although further high quality longitudinal studies are needed to confirm these findings and evaluate the magnitude of these associations, our findings suggest a role of inflammation in the pathogenesis of nonspecific LBP.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Review Articles Source Type: research
Discussion: The results of this review show that there is a need to improve the methodological quality of guidelines for procedural pain in newborns. The set of recommendations for procedural pain prevention needs to involve not only pharmacological and nonpharmacological pain treatment but also parents and interprofessional collaboration. It is also essential to take into account facilitators, barriers, and the context to improve pain management.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Review Articles Source Type: research
Objective: Tapentadol (TAP) immediate release (IR) is a newer opioid option for acute pain. The aim of this systematic review was to examine the efficacy and safety of TAP IR compared with other opioids for acute pain. Methods: A systematic literature search as conducted using the Cochrane Library, Embase, International Pharmaceutical Abstracts, MEDLINE, PubMed, and Web of Science. The search included all randomized controlled trials and observational studies examining TAP IR versus other orally administered IR opioids for acute pain. The protocol for this study was registered on PROSPERO (CRD42018110267). Results: ...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Review Articles Source Type: research
Objective: The present study assessed somatosensory changes related to trigeminal nerve damage using extensive evaluation tools and assessed the effect of such damage on the patients’ psychosocial status and quality of life compared with healthy participants. Methods: In 37 patients with intraorally or extraorally presenting trigeminal nerve damage diagnosed as painful or nonpainful posttraumatic trigeminal neuropathy, psychophysical tests like quantitative sensory testing (QST) and qualitative sensory testing and the electrophysiological “nociceptive-specific” blink reflex were performed. The patien...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
This study examines the relationship between quantitative sensory testing (QST) and clinical measures of pain sensitization in people with knee OA. Methods: A secondary analysis of data from 134 participants with knee OA was performed. Clinical measures included: manual tender point count (MTPC), the Central Sensitization Inventory (CSI) to capture centrally mediated comorbidities, number of painful sites on a body chart, and neuropathic pain-like symptoms assessed using the modified PainDetect Questionnaire. Relationships between clinical measures and QST measures of pressure pain thresholds (PPTs), temporal summation,...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Boston-headquartered Orbita, a healthcare innovation company offering conversational AI platform and virtual health assistant solutions, has released the OrbitaASSIST, a voice-powered, AI-driven bedside virtual assistant. Patients use a smart speaker...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Informatics Source Type: blogs
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