The use of dehydrated amniotic membrane allograft for augmentation of dural repair in transsphenoidal endoscopic endonasal resection of pituitary adenomas

ConclusionsThis feasibility study demonstrates that dehydrated amniotic membrane allograft can be safely utilized as an adjunct during sellar closures for TEES for pituitary adenoma resection with very low rates of CSF leak and meningitis.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research

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Streptococcus pneumoniae is a Gram-positive bacterium belonging to the oral streptococcus species, mitis group. This pathogen is a leading cause of community-acquired pneumonia, which often evades host immunity and causes systemic diseases, such as sepsis and meningitis. Previously, we reported that PfbA is a β-helical cell surface protein contributing to pneumococcal adhesion to and invasion of human epithelial cells in addition to its survival in blood. In the present study, we investigated the role of PfbA in pneumococcal pathogenesis. Phylogenetic analysis indicated that the pfbA gene is highly conserved in S. pne...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conditions:   Serogroup C Meningococcal Meningitis;   Diphtheria Intervention:   Procedure: venepuncture Sponsor:   University of Oxford Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In Reply We thank Burstein and Papenburg, Verd and Moll, and Bonadio for the letters pertaining to our study in which we derived and validated a prediction rule for identifying febrile infants 60 days and younger with serious bacterial infections (SBI). Burstein and Papenburg question the use of the less widely available procalcitonin (PCT) rather than the C-reactive protein. They also suggest considering results of viral multiplex testing in the prediction rule. We chose PCT because of its superiority as a screening biomarker compared with C-reactive protein for invasive bacterial infections (bacteremia and/or bacterial m...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
AbstractThe surgical approach for hypophysectomy has undergone sweeping revolution in the past three decades. With the advent of endoscopes, better instrumentation, better illumination and viewing cameras, endoscopic endo-nasal trans-sphenoidal approach to sella has now largely become the norm. The aim of this study is to present our experience, analysing the surgical outcomes of this approach in patients with pituitary adenoma, pertaining to entirety of tumor removal, alleviation of symptoms and rate of complications. This prospective   study was conducted at our tertiary health care  centre from June 2012 ...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
Lenggenhager Cordey Kaiser : Meningitis, encephalitis, and myelitis are various forms of acute central nervous system (CNS) inflammation, which can coexist and lead to serious sequelae. Known aetiologies include infections and immune-mediated processes. Despite advances in clinical microbiology over the past decades, the cause of acute CNS inflammation remains unknown in approximately 50% of cases. High-throughput sequencing was performed to search for viral sequences in cerebrospinal fluid (CSF) samples collected from 26 patients considered to have acute CNS inflammation of unknown origin, and 10 patients wit...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Publication date: Available online 16 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): A. Skalnaya, V. Fominykh, R. Ivashchenko, D. Averchenkov, L. Grazhdantseva, N. Frigo, E. Negasheva, O. Dolya, L. Brylev, A. GuekhtAbstractThe term of neurosyphilis (NS) refers to infection of central nervous system by Treponema pallidum. Classically, it has been divided into early (meningitis, meningovascular) and late forms (general paresis and tabes dorsalis). The availability of penicillin and high sensitivity of Treponema pallidum to this antibiotic has led to a widely held perception about rarity of syphilitic forms wit...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
In this report, considering also the literature information, a case of G.sanguinis which is thought to cause meningitis was presented. Our case is a 39-year-old female patient with a lumboperitoneal shunt. The patient was admitted to the neurosurgery clinic with a headache and vision loss and was hospitalized in the service with a pre-diagnosis of pseudotumor cerebri. Neurological examination revealed no pathological findings. Eye examination revealed mild papillary edema, local retinal hemorrhage, and bilateral expansion in retinal vascularization. There was no pathologic findings in the brain magnetic resonance imaging. ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
We report a case of K. variicola meningitis after neurosurgery. The bacterium was isolated from blood and cerebrospinal fluid, and bacterial species identification was carried out by using both matrix-assisted laser-desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) and whole genome sequencing. Initially, the organism was misidentified as K. pneumoniae by VITEK®2; automated system in the clinical laboratory examination. The patient recovered with the combination of surgical drainage and antimicrobial treatment. To our knowledge, this is the first case report of post-surgical meningitis caused by K. v...
Source: IDCases - Category: Infectious Diseases Source Type: research
Background: Few studies report hearing preservation following middle cranial fossa (MCF) floor defect repair. Objective: To investigate audiological outcomes following MCF floor defect repair using a modified MCF suprapetrous approach. Study Design: Retrospective cohort. Setting: Tertiary referral center. Patients: Eleven patients, with MCF floor defects. Interventions: MCF floor defect surgical repairs with either fascia or fascia and bone graft. Main Outcome Measured: Hearing outcomes. Results: Eleven patients (two men) aged 34 to 82 years (median, 62 yrs) were identified. All patients were operate...
Source: Otology and Neurotology - Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research
AbstractThe role of otolaryngologist in the management of CSF rhinorrhea is expanding. It is prudent to evaluate all cases of CSF leak, understand the etiological causes and formalize a working approach to management of such cases to yield better outcome. A retrospective descriptive study of 39 cases of proven CSF rhinorrhea treated at a tertiary care center between January 2014 to August 2019. The data retrieved were analyzed for age, gender, weight, etiology, recurrence of the disease, history of meningitis, nasal or neurosurgical intervention in past, imaging inform of CT and MR cisternography as and when required. This...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
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